| Literature DB >> 11214134 |
A Lafeuillade, G Hittinger, S Chadapaud.
Abstract
In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.Entities:
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Year: 2001 PMID： 11214134 DOI： 10.1016/S0140-6736(00)03618-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321