Literature DB >> 11212127

Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.

M Schlitzer1, A Winter-Vann, P J Casey.   

Abstract

Several compounds designed as bisubstrate analogues of protein farnesyltransferase inhibited the prenyl protein-specific protease Rce1, qualifying them as lead structures for a novel class of non-peptidic, non-prenylic inhibitors of this protease.

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Year:  2001        PMID： 11212127     DOI： 10.1016/s0960-894x(00)00685-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

Review 1.  Therapeutic intervention based on protein prenylation and associated modifications.

Authors:  Michael H Gelb; Lucas Brunsveld; Christine A Hrycyna; Susan Michaelis; Fuyuhiko Tamanoi; Wesley C Van Voorhis; Herbert Waldmann
Journal:  Nat Chem Biol       Date:  2006-10       Impact factor: 15.040

2.  Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

Authors:  Stephen B Porter; Emily R Hildebrandt; Sarah R Breevoort; David Z Mokry; Timothy M Dore; Walter K Schmidt
Journal:  Biochim Biophys Acta       Date:  2007-03-20

Review 3.  Regulating the regulator: post-translational modification of RAS.

Authors:  Ian M Ahearn; Kevin Haigis; Dafna Bar-Sagi; Mark R Philips
Journal:  Nat Rev Mol Cell Biol       Date:  2011-12-22       Impact factor: 94.444

Review 4.  Small change, big effect: Taking RAS by the tail through suppression of post-prenylation carboxylmethylation.

Authors:  Hiu Yeung Lau; Mei Wang
Journal:  Small GTPases       Date:  2018-01-25

5.  Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.

Authors:  Anne-Marie R Dechert; James P MacNamara; Sarah R Breevoort; Emily R Hildebrandt; Ned W Hembree; Adam C Rea; Duncan E McLain; Stephen B Porter; Walter K Schmidt; Timothy M Dore
Journal:  Bioorg Med Chem       Date:  2010-07-21       Impact factor: 3.641

6.  Chemical inhibition of CaaX protease activity disrupts yeast Ras localization.

Authors:  Surya P Manandhar; Emily R Hildebrandt; William H Jacobsen; George M Santangelo; Walter K Schmidt
Journal:  Yeast       Date:  2010-06       Impact factor: 3.239

7.  Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T.

Authors:  Florian Fueller; Martin O Bergo; Stephen G Young; Klaus Aktories; Gudula Schmidt
Journal:  Infect Immun       Date:  2006-03       Impact factor: 3.441

8.  Heterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets.

Authors:  David Z Mokry; Surya P Manandhar; Kristen A Chicola; George M Santangelo; Walter K Schmidt
Journal:  Eukaryot Cell       Date:  2009-10-09

9.  Small-molecule inhibitors of the Rce1p CaaX protease.

Authors:  Surya P Manandhar; Emily R Hildebrandt; Walter K Schmidt
Journal:  J Biomol Screen       Date:  2007-10

10.  8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

Authors:  Idrees Mohammed; Shahienaz E Hampton; Louise Ashall; Emily R Hildebrandt; Robert A Kutlik; Surya P Manandhar; Brandon J Floyd; Haley E Smith; Jonathan K Dozier; Mark D Distefano; Walter K Schmidt; Timothy M Dore
Journal:  Bioorg Med Chem       Date:  2015-11-30       Impact factor: 3.641
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