Literature DB >> 11212126

Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.

J Wiesner1, A Mitsch, P Wissner, H Jomaa, M Schlitzer.   

Abstract

We have described compound 1 as a lead structure for a novel class of anti-malarial agents. Replacement of the 3-phenylpropionyl moiety of the lead structure 1 by a 4-propoxycinnamic acid residue resulted in a significant improvement in antimalarial activity. Compound 3q represents an important step in the development of lead structure 1 into an anti-malarial drug candidate.

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Year:  2001        PMID： 11212126     DOI： 10.1016/s0960-894x(00)00684-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening.

Authors:  Leigh M Matano; Heidi G Morris; B McKay Wood; Timothy C Meredith; Suzanne Walker
Journal:  Bioorg Med Chem       Date:  2016-08-16       Impact factor: 3.641

2.  2-Methyl-3-(3-methyl-phen-yl)acrylic acid.

Authors:  Niaz Muhammad; Saqib Ali; M Nawaz Tahir
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-07-05

Review 3.  Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity.

Authors:  Juan David Guzman
Journal:  Molecules       Date:  2014-11-25       Impact factor: 4.411

4.  In Vitro Anti-Toxoplasma gondii and Antimicrobial Activity of Amides Derived from Cinnamic Acid.

Authors:  Graziela Rangel Silveira; Karoline Azerêdo Campelo; Gleice Rangel Silveira Lima; Lais Pessanha Carvalho; Solange Silva Samarão; Olney Vieira-da-Motta; Leda Mathias; Carlos Roberto Ribeiro Matos; Ivo José Curcino Vieira; Edesio José Tenório de Melo; Edmilson José Maria
Journal:  Molecules       Date:  2018-03-28       Impact factor: 4.411

5.  Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Authors:  Pi-Hui Liang; Wei-Chieh Cheng; Yi-Ling Lee; Han-Pang Yu; Ying-Ta Wu; Yi-Ling Lin; Chi-Huey Wong
Journal:  Chembiochem       Date:  2006-01       Impact factor: 3.164

Review 6.  Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs.

Authors:  Ana Teresa Silva; Clara M Bento; Ana C Pena; Luísa M Figueiredo; Cristina Prudêncio; Luísa Aguiar; Tânia Silva; Ricardo Ferraz; Maria Salomé Gomes; Cátia Teixeira; Paula Gomes
Journal:  Molecules       Date:  2019-12-24       Impact factor: 4.411
  6 in total

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