| Literature DB >> 11212124 |
C Zhou1, L Guo, G Morriello, A Pasternak, Y Pan, S P Rohrer, E T Birzin, S E Huskey, T Jacks, K D Schleim, K Cheng, J M Schaeffer, A A Patchett, L Yang.
Abstract
N-Substituted nipecotic and iso-nipecotic amides of beta-methylTrpLys tert-butyl ester were found to be novel, selective and potent agonists of the somatostatin subtype-2 receptor in vitro. For example iso-nipecotic amide 8a showed high hsst2 binding affinity (Ki = 0.5 nM) and good selectivity (h5/h2 = 832).Entities:
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Year: 2001 PMID： 11212124 DOI： 10.1016/s0960-894x(00)00687-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823