| Literature DB >> 11212121 |
G Sorba1, M Bertinaria, A Di Stilo, A Gasco, M M Scaltrito, M I Brenciaglia, F Dubini.
Abstract
New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.Entities:
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Year: 2001 PMID： 11212121 DOI： 10.1016/s0960-894x(00)00671-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823