| Literature DB >> 11212115 |
L L Brockunier1, M R Candelore, M A Cascieri, Y Liu, L Tota, M J Wyvratt, M H Fisher, A E Weber, E R Parmee.
Abstract
Pyridineethanolamine derivatives containing cyanoguanidine or nitroethylenediamine moieties were examined as human beta3 adrenergic receptor (AR) agonists. Notably, indoline derivatives 6a and 11 were potent beta3 AR agonists (beta3 EC50 = 13 and 19 nM, respectively), which showed good selectivity over binding to and minimal activation of the beta1 and beta2 ARs.Entities:
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Year: 2001 PMID： 11212115 DOI： 10.1016/s0960-894x(00)00669-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823