| Literature DB >> 11212103 |
X Tian1, L W Hsin, E L Webster, C Contoreggi, G P Chrousos, P W Gold, K Habib, A Ayala, W C Eckelman, A E Jacobson, K C Rice.
Abstract
A high-affinity radioligand for CRHR1 has been prepared that can serve as a template for the development of SPECT imaging agents. The 5-chloro-N-cyclopropylmethyl-N-(2,6-dichloro-4-iodophenyl)-2-methyl-N-propylpyrimidine-4,6-diamine (6b, Ki = 14 nM), and the corresponding 4-bromophenyl analogue (6a, Ki = 21 nM), were synthesized in four steps from compound 3.Entities:
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Year: 2001 PMID： 11212103 DOI： 10.1016/s0960-894x(00)00661-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823