| Literature DB >> 1120984 |
J Hannah, K Kelly, A A Patchett.
Abstract
The synthesis of a series of substituted pyrazolo corticoids is described. Of these 11beta,17alpha,21-trihydroxy-6,16alpha-dimethyl-4,6-pregnadieno[3,2-c]-2'-(4-pyridly)pyrazole (21) shows an excellent separation of systemic to local activity in the model animal test. Compound 21 exhibits high vasoconstriction activity in human volunteers and is clinically effective in the treatment of psoriasis.Entities:
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Year: 1975 PMID： 1120984 DOI： 10.1021/jm00236a012
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446