Literature DB >> 11208611

Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.

M Soleimani1, T Greeley, S Petrovic, Z Wang, H Amlal, P Kopp, C E Burnham.   

Abstract

The identities of the apical Cl-/base exchangers in kidney proximal tubule and cortical collecting duct (CCD) cells remain unknown. Pendrin (PDS), which is expressed at high levels in the thyroid and its mutation causes Pendred's syndrome, is shown to be an anion exchanger. We investigated the renal distribution of PDS and its function. Our results demonstrate that pendrin mRNA expression in the rat kidney is abundant and limited to the cortex. Proximal tubule suspensions isolated from kidney cortex were highly enriched in pendrin mRNA. Immunoblot analysis studies localized pendrin to cortical brush-border membranes. Nephron segment RT-PCR localized pendrin mRNA to proximal tubule and CCD. Expression studies in HEK-293 cells demonstrated that pendrin functions in the Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange modes. The conclusion is that pendrin is an apical Cl-/base exchanger in the kidney proximal tubule and CCD and mediates Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange.

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Year:  2001        PMID： 11208611     DOI： 10.1152/ajprenal.2001.280.2.F356

Source DB:  PubMed          Journal:  Am J Physiol Renal Physiol        ISSN： 1522-1466


  84 in total

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2.  Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells.

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4.  Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion.

Authors:  I E Royaux; S M Wall; L P Karniski; L A Everett; K Suzuki; M A Knepper; E D Green
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

5.  Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD).

Authors:  Wen Liu; Núria M Pastor-Soler; Carlos Schreck; Beth Zavilowitz; Thomas R Kleyman; Lisa M Satlin
Journal:  Am J Physiol Renal Physiol       Date:  2011-09-28

6.  Distribution of pendrin in the organ of Corti of mice observed by electron immunomicroscopy.

Authors:  Takahiko Yoshino; Eisuke Sato; Tsutomu Nakashima; Masaaki Teranishi; Hiroshi Yamamoto; Hironao Otake; Terukazu Mizuno
Journal:  Eur Arch Otorhinolaryngol       Date:  2006-05-16       Impact factor: 2.503

7.  Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice.

Authors:  Ursula Seidler; Ingrid Rottinghaus; Jutta Hillesheim; Mingmin Chen; Brigitte Riederer; Anja Krabbenhöft; Regina Engelhardt; Martin Wiemann; Zhaouhui Wang; Sharon Barone; Michael P Manns; Manoocher Soleimani
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8.  The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct.

Authors:  Nikolay Shcheynikov; Dongki Yang; Youxue Wang; Weizong Zeng; Lawrence P Karniski; Insuk So; Susan M Wall; Shmuel Muallem
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9.  Role of pendrin in iodide balance: going with the flow.

Authors:  Young Hee Kim; Truyen D Pham; Wencui Zheng; Seongun Hong; Christine Baylis; Vladimir Pech; William H Beierwaltes; Donna B Farley; Lewis E Braverman; Jill W Verlander; Susan M Wall
Journal:  Am J Physiol Renal Physiol       Date:  2009-07-15

10.  Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure.

Authors:  Manoocher Soleimani; Sharon Barone; Jie Xu; Gary E Shull; Faraz Siddiqui; Kamyar Zahedi; Hassane Amlal
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-30       Impact factor: 11.205
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