Literature DB >> 11207394

Modulation of neuronal activity in the nucleus raphé magnus by the 5-HT(1)-receptor agonist naratriptan in rat.

Jens Ellrich1, Karl Messlinger, Chen Yu Chiang, James W Hu.   

Abstract

Modulatory effects of the new antimigraine drug naratriptan, a 5-HT(1)-receptor-agonist, on neurons of the nucleus raphé magnus were examined in rat by extracellular recordings. In the nucleus raphé magnus neuronal activity decreased in on-cells and increased in off-cells after intravenous administration of naratriptan. The modulatory effects of naratriptan were similar to the well-known effects of morphine on neurons in the nucleus raphé magnus. The results of this study suggest central actions of naratriptan and may point to an involvement of the endogenous pain control system in the antinociceptive effects of the 5-HT(1)-receptor-agonist.

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Year:  2001        PMID： 11207394     DOI： 10.1016/S0304-3959(00)00405-X

Source DB:  PubMed          Journal:  Pain        ISSN： 0304-3959            Impact factor:   6.961


  8 in total

1.  The neurobiology of migraine.

Authors:  Andrew Charles; K C Brennan
Journal:  Handb Clin Neurol       Date:  2010

2.  Activation of rostral ventromedial medulla neurons by noxious stimulation of cutaneous and deep craniofacial tissues.

Authors:  Sergey G Khasabov; Patrick Malecha; Joseph Noack; Janneta Tabakov; Keiichiro Okamoto; David A Bereiter; Donald A Simone
Journal:  J Neurophysiol       Date:  2014-09-03       Impact factor: 2.714

3.  Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients.

Authors:  Ronald G Garcia; Richard L Lin; Jeungchan Lee; Jieun Kim; Riccardo Barbieri; Roberta Sclocco; Ajay D Wasan; Robert R Edwards; Bruce R Rosen; Nouchine Hadjikhani; Vitaly Napadow
Journal:  Pain       Date:  2017-08       Impact factor: 6.961

Review 4.  Preclinical neuropharmacology of naratriptan.

Authors:  Geoffrey A Lambert
Journal:  CNS Drug Rev       Date:  2005

Review 5.  Pathophysiology of Migraine: A Disorder of Sensory Processing.

Authors:  Peter J Goadsby; Philip R Holland; Margarida Martins-Oliveira; Jan Hoffmann; Christoph Schankin; Simon Akerman
Journal:  Physiol Rev       Date:  2017-04       Impact factor: 37.312

Review 6.  Tolerability of the triptans: clinical implications.

Authors:  Giuseppe Nappi; Giorgio Sandrini; Grazia Sances
Journal:  Drug Saf       Date:  2003       Impact factor: 5.606

Review 7.  Migraine: where and how does the pain originate?

Authors:  Karl Messlinger
Journal:  Exp Brain Res       Date:  2009-03-14       Impact factor: 1.972

8.  Evaluation of c-Fos immunoreactivity in the rat brainstem nuclei relevant in migraine pathogenesis after electrical stimulation of the trigeminal ganglion.

Authors:  Zsuzsanna Bohár; Annamária Fejes-Szabó; Lilla Tar; Hedvig Varga; János Tajti; Árpád Párdutz; László Vécsei
Journal:  Neurol Sci       Date:  2013-01-25       Impact factor: 3.307
  8 in total

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