Literature DB >> 11207325

Role of serotonin in the behavioral and psychological symptoms of dementia.

K L Lanctôt, N Herrmann, P Mazzotta.   

Abstract

The behavioral and psychological symptoms of dementia (BPSD) can have serious debilitating effects on the patient and increase caregiver burden. Investigations into the underlying neuropathology indicate that the serotonergic system may contribute to BPSD. In addition, serotonergic pathways are known to interact extensively with the cholinergic, noradrenergic, GABAergic, and dopaminergic systems. Hence, serotonergic therapies may be used to manipulate other neurotransmitters systems to alleviate BPSD or in combination with agents specific for the other neurotransmitter receptor sites. Neurotransmitter-modulated behaviors and evidence provided by pharmacological interventions are reviewed, focusing primarily on the serotonergic system.

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Year:  2001        PMID： 11207325     DOI： 10.1176/jnp.13.1.5

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN： 0895-0172            Impact factor:   2.198


  30 in total

Review 1.  Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer's Disease.

Authors:  Celina S Liu; Sarah A Chau; Myuri Ruthirakuhan; Krista L Lanctôt; Nathan Herrmann
Journal:  CNS Drugs       Date:  2015-08       Impact factor: 5.749

2.  Development of the human insular cortex: differentiation, proliferation, cell death, and appearance of 5HT-2A receptors.

Authors:  Maria S M Wai; Chun Shi; W H Kwong; Lihong Zhang; Wai Ping Lam; David T Yew
Journal:  Histochem Cell Biol       Date:  2008-09-02       Impact factor: 4.304

3.  Establishment and characterization of RNA-edited serotonin 2C receptor isoform cell models and alteration of amyloid precursor protein ectodomain secretion in HEK293 APPSwe cells.

Authors:  Lingchen Guo; Jing Zhang; Qixin Yan; Ming Yin
Journal:  Hum Cell       Date:  2011-05-17       Impact factor: 4.174

4.  Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease.

Authors:  Mitchell K P Lai; Shirley W Tsang; Margaret M Esiri; Paul T Francis; Peter T-H Wong; Christopher P Chen
Journal:  Psychopharmacology (Berl)       Date:  2010-07-13       Impact factor: 4.530

Review 5.  Serotonergic system, cognition, and BPSD in Alzheimer's disease.

Authors:  Saikat Chakraborty; Jack C Lennon; Sridhar A Malkaram; Yan Zeng; Daniel W Fisher; Hongxin Dong
Journal:  Neurosci Lett       Date:  2019-04-01       Impact factor: 3.046

6.  A roadmap for investigating the role of the prion protein in depression associated with neurodegenerative disease.

Authors:  Danielle Beckman; Rafael Linden
Journal:  Prion       Date:  2016-03-03       Impact factor: 3.931

7.  Soluble beta amyloid(1-42): a critical player in producing behavioural and biochemical changes evoking depressive-related state?

Authors:  M Colaianna; P Tucci; M Zotti; M G Morgese; S Schiavone; S Govoni; V Cuomo; L Trabace
Journal:  Br J Pharmacol       Date:  2010-03-09       Impact factor: 8.739

8.  Delusions and hallucinations are associated with worse outcome in Alzheimer disease.

Authors:  Nikolaos Scarmeas; Jason Brandt; Marilyn Albert; Georgios Hadjigeorgiou; Alexandros Papadimitriou; Bruno Dubois; Maria Sarazin; Davangere Devanand; Lawrence Honig; Karen Marder; Karen Bell; Domonick Wegesin; Deborah Blacker; Yaakov Stern
Journal:  Arch Neurol       Date:  2005-10

Review 9.  Towards defining restlessness in individuals with dementia.

Authors:  Natalie G Regier; Laura N Gitlin
Journal:  Aging Ment Health       Date:  2016-01-08       Impact factor: 3.658

10.  Disruptive behavior as a predictor in Alzheimer disease.

Authors:  Nikolaos Scarmeas; Jason Brandt; Deborah Blacker; Marilyn Albert; Georgios Hadjigeorgiou; Bruno Dubois; Davangere Devanand; Lawrence Honig; Yaakov Stern
Journal:  Arch Neurol       Date:  2007-12
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