D Hacking1, A Watkins, S Fraser, R Wolfe, T Nolan. 1. Department of Paediatrics, Mercy Hospital for Women, Clarendon Street, East Melbourne, Victoria 3002, Australia. doug.hacking@imm.ox.ac.uk
Abstract
OBJECTIVE: To determine the effect of birth order on respiratory distress syndrome (RDS) in the outcome of twins in a large premature population managed in a modern neonatal intensive care unit. METHODS: An historical cohort study design was used to analyse the neonatal outcomes of 301 premature liveborn twin sibling pairs of between 23 and 31 weeks gestation from the Australia and New Zealand Neonatal Network 1995 database. RESULTS: Among the 56 twin sibling pairs who were discordant for RDS, the second twin was affected in 41 cases (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.5 to 5.3). The excess risk of RDS in the second twin increased with gestation and was statistically significant for twins above 29 weeks gestation (OR 4.4, 95% CI 1.6 to 15). CONCLUSIONS: There is a significant increased risk of RDS associated with being the second born of premature twins, which appears to depend on gestation.
OBJECTIVE: To determine the effect of birth order on respiratory distress syndrome (RDS) in the outcome of twins in a large premature population managed in a modern neonatal intensive care unit. METHODS: An historical cohort study design was used to analyse the neonatal outcomes of 301 premature liveborn twin sibling pairs of between 23 and 31 weeks gestation from the Australia and New Zealand Neonatal Network 1995 database. RESULTS: Among the 56 twin sibling pairs who were discordant for RDS, the second twin was affected in 41 cases (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.5 to 5.3). The excess risk of RDS in the second twin increased with gestation and was statistically significant for twins above 29 weeks gestation (OR 4.4, 95% CI 1.6 to 15). CONCLUSIONS: There is a significant increased risk of RDS associated with being the second born of premature twins, which appears to depend on gestation.
Authors: Seung Mi Lee; Joong Shin Park; Errol R Norwitz; Sun Min Kim; JoonHo Lee; Chan-Wook Park; Byoung Jae Kim; Jong Kwan Jun Journal: PLoS One Date: 2015-06-15 Impact factor: 3.240
Authors: Yoshie Yokoyama; Aline Jelenkovic; Reijo Sund; Joohon Sung; John L Hopper; Syuichi Ooki; Kauko Heikkilä; Sari Aaltonen; Adam D Tarnoki; David L Tarnoki; Gonneke Willemsen; Meike Bartels; Toos C E M van Beijsterveldt; Kimberly J Saudino; Tessa L Cutler; Tracy L Nelson; Keith E Whitfield; Jane Wardle; Clare H Llewellyn; Abigail Fisher; Mingguang He; Xiaohu Ding; Morten Bjerregaard-Andersen; Henning Beck-Nielsen; Morten Sodemann; Yun-Mi Song; Sarah Yang; Kayoung Lee; Hoe-Uk Jeong; Ariel Knafo-Noam; David Mankuta; Lior Abramson; S Alexandra Burt; Kelly L Klump; Juan R Ordoñana; Juan F Sánchez-Romera; Lucia Colodro-Conde; Jennifer R Harris; Ingunn Brandt; Thomas Sevenius Nilsen; Jeffrey M Craig; Richard Saffery; Fuling Ji; Feng Ning; Zengchang Pang; Lise Dubois; Michel Boivin; Mara Brendgen; Ginette Dionne; Frank Vitaro; Nicholas G Martin; Sarah E Medland; Grant W Montgomery; Patrik K E Magnusson; Nancy L Pedersen; Anna K Dahl Aslan; Per Tynelius; Claire M A Haworth; Robert Plomin; Esther Rebato; Richard J Rose; Jack H Goldberg; Finn Rasmussen; Yoon-Mi Hur; Thorkild I A Sørensen; Dorret I Boomsma; Jaakko Kaprio; Karri Silventoinen Journal: Twin Res Hum Genet Date: 2016-04 Impact factor: 1.587