AIMS: To investigate pancreatic function in children attending an obesity clinic. METHODS: Thirty six children (of which 34 were white) with severe obesity of prepubertal onset (body mass index more than +2 SDS) were reviewed clinically and dysmorphologically, with assessment of pancreatic function. RESULTS: Eight had dysmorphic features and 13 had learning difficulties. Four of 17 prepubertal children had hyperinsulinaemia and seven had hyperproinsulinaemia. All 19 pubertal children had hyperinsulinaemia, 14 had hyperproinsulinaemia, and one had type II diabetes. CONCLUSIONS: Metabolic abnormalities predictive of type II diabetes occur in severely obese white children.
AIMS: To investigate pancreatic function in children attending an obesity clinic. METHODS: Thirty six children (of which 34 were white) with severe obesity of prepubertal onset (body mass index more than +2 SDS) were reviewed clinically and dysmorphologically, with assessment of pancreatic function. RESULTS: Eight had dysmorphic features and 13 had learning difficulties. Four of 17 prepubertal children had hyperinsulinaemia and seven had hyperproinsulinaemia. All 19 pubertal children had hyperinsulinaemia, 14 had hyperproinsulinaemia, and one had type II diabetes. CONCLUSIONS:Metabolic abnormalities predictive of type II diabetes occur in severely obese white children.
Authors: C P Smith; H R Archibald; J M Thomas; A C Tarn; A J Williams; E A Gale; M O Savage Journal: Clin Endocrinol (Oxf) Date: 1988-01 Impact factor: 3.478
Authors: Hans-Erik Johansson; Arvo Haenni; F Anders Karlsson; Britt Edén-Engström; Margareta Ohrvall; Magnus Sundbom; Björn Zethelius Journal: Obes Surg Date: 2010-05 Impact factor: 4.129
Authors: H-E Johansson; M Ohrvall; A Haenni; M Sundbom; B Edén Engström; F A Karlsson; B Zethelius Journal: Diabet Med Date: 2007-09-26 Impact factor: 4.359