| Literature DB >> 11206480 |
D Ma1, T Zhang, G Wang, A P Kozikowski, N E Lewin, P M Blumberg.
Abstract
7-Methoxy-8-decynyl-benzolactam-V8 4 is synthesized using a catalytic asymmetric alkylation reaction as a key step. This compound shows potent activity to three PKC isozymes tested (Ki =45.6, 91.1, and 121.3 nM to PKCalpha, delta, and epsilon, respectively), indicating that introduction of a suitable substituent at the 7-position of 8-decynyl-benzolactam-V8 only slightly reduces the PKC binding affinity.Entities:
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Year: 2001 PMID： 11206480 DOI： 10.1016/s0960-894x(00)00609-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823