Literature DB >> 11206478

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.

W T Sing1, C L Lee, S L Yeo, S P Lim, M M Sim.   

Abstract

Arylalkylidene rhodanines 2(a-d) inhibit HCV NS3 protease at moderate concentrations. They are better inhibitors of other serine proteases such as chymotrypsin and plasmin. However, the selectivity of arylmethyliden e rhodanines (8a, 9a) with bulkier and more hydrophobic functional groups increases by 13- and 25-fold towards HCV NS3 protease respectively.

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Year:  2001        PMID： 11206478     DOI： 10.1016/s0960-894x(00)00610-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  22 in total

1.  Testing the ability of rhodanine and 2, 4-thiazolidinedione to interact with the human pancreatic alpha-amylase: electron-density descriptors complement molecular docking, QM, and QM/MM dynamics calculations.

Authors:  Rajendran Niranjana Devi; Maria G Khrenova; Samuel Israel; Chellam Anzline; Andrey A Astakhov; Vladimir G Tsirelson
Journal:  J Mol Model       Date:  2017-08-05       Impact factor: 1.810

2.  An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors.

Authors:  Sukanta Kamila; Haribabu Ankati; Edward R Biehl
Journal:  Tetrahedron Lett       Date:  2011-08-24       Impact factor: 2.415

3.  Three-component, one-flask synthesis of rhodanines (thiazolidinones).

Authors:  Alexander M Jacobine; Gary H Posner
Journal:  J Org Chem       Date:  2011-08-31       Impact factor: 4.354

4.  Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors.

Authors:  Yang Xiang; Cheng Chen; Wen-Ming Wang; Li-Wei Xu; Ke-Wu Yang; Peter Oelschlaeger; Yuan He
Journal:  ACS Med Chem Lett       Date:  2018-03-22       Impact factor: 4.345

5.  New 5-ylidene rhodanine derivatives based on the dispacamide A model.

Authors:  Solene Guiheneuf; Ludovic Paquin; François Carreaux; Emilie Durieu; Thierry Roisnel; Laurent Meijer; Jean-Pierre Bazureau
Journal:  Mol Divers       Date:  2014-03-02       Impact factor: 2.943

6.  3-Phenyl-2-thioxo-1,3-thia-zolidin-4-one.

Authors:  Feng-Xia Zhu; Jian-Feng Zhou; Gui-Xia Gong
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-09-24

7.  Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.

Authors:  N D Sonawane; A S Verkman
Journal:  Bioorg Med Chem       Date:  2008-07-23       Impact factor: 3.641

8.  Influence of substituent effects on spectroscopic properties and antimicrobial activity of 5-(4'-substituted phenylazo)-2-thioxothiazolidinone derivatives.

Authors:  M I Abou-Dobara; A Z El-Sonbati; Sh M Morgan
Journal:  World J Microbiol Biotechnol       Date:  2012-09-12       Impact factor: 3.312

9.  Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity.

Authors:  Yee-Ling Khu; Yee-Joo Tan; Seng Gee Lim; Wanjin Hong; Phuay-Yee Goh
Journal:  Biochem J       Date:  2004-12-01       Impact factor: 3.857

10.  Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.

Authors:  Guang-Cheng Wang; Ya-Ping Peng; Zhen-Zhen Xie; Jing Wang; Ming Chen
Journal:  Medchemcomm       Date:  2017-05-31       Impact factor: 3.597
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