| Literature DB >> 11206466 |
X Ding1, M D Vera, B Liang, Y Zhao, M S Leonard, M M Joullié.
Abstract
The synthesis and antitumor activity of a novel didemnin B analogue containing a psi[CH2NH] amide bond surrogate between N-Me-D-Leu7 and Pro8 are reported. The analogue shows activity (GI50 = 4 nM) comparable to that of didemnin B (GI50 = 13 nM) in the NCI-60 tumor cell screen. This result, along with new data from previously reported synthetic didemnin analogues, is discussed within the context of the side-chain SAR for didemnins.Entities:
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Year: 2001 PMID： 11206466 DOI： 10.1016/s0960-894x(00)00638-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823