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Literature DB >> 11206451

Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore.

J McNulty¹, J Mao, R Gibe, R Mo, S Wolf, G R Pettit, D L Herald, M R Boyd.

Abstract

Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.

Entities: Chemical Disease

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Year: 2001 PMID： 11206451 DOI： 10.1016/s0960-894x(00)00614-4

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

15 in total

1. Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine.

Authors: Jonathan Collins; Uwe Rinner; Michael Moser; Tomas Hudlicky; Ion Ghiviriga; Anntherese E Romero; Alexander Kornienko; Dennis Ma; Carly Griffin; Siyaram Pandey
Journal: J Org Chem Date: 2010-05-07 Impact factor: 4.354

Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore.

1. Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine.

2. Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation.

Review 3. Chemistry, biology, and medicinal potential of narciclasine and its congeners.

4. Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities.

5. TOTAL SYNTHESES OF PANCRATISTATIN. A REVIEW.

6. Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family.

7. Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity.

8. Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide.

9. Amaryllidaceae isocarbostyril alkaloids and their derivatives as promising antitumor agents.

10. Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.