| Literature DB >> 11206448 |
W Pendergast1, B R Yerxa, J G Douglass, S R Shaver, R W Dougherty, C C Redick, I F Sims, J L Rideout.
Abstract
A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.Entities:
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Year: 2001 PMID： 11206448 DOI： 10.1016/s0960-894x(00)00612-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823