Literature DB >> 11206447

Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.

N Kaila1, B E Thomas, P Thakker, J C Alvarez, R T Camphausen, D Crommie.   

Abstract

The design and synthesis of novel beta-C-mannosides that inhibit the binding of sialyl Lewis x to E-selectin are described. Compounds that contained a phenyl substituent at the C-6 position were found to have increased potency.

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Year:  2001        PMID: 11206447     DOI: 10.1016/s0960-894x(00)00623-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.

Authors:  Abdel Kareem Azab; Phong Quang; Feda Azab; Costas Pitsillides; Brian Thompson; Triona Chonghaile; John T Patton; Patricia Maiso; Val Monrose; Antonio Sacco; Hai T Ngo; Ludmila M Flores; Charles P Lin; John L Magnani; Andrew L Kung; Anthony Letai; Ruben Carrasco; Aldo M Roccaro; Irene M Ghobrial
Journal:  Blood       Date:  2011-11-16       Impact factor: 22.113

2.  Development of quinic acid-conjugated nanoparticles as a drug carrier to solid tumors.

Authors:  Zohreh Amoozgar; Joonyoung Park; Qingnuo Lin; Johann H Weidle; Yoon Yeo
Journal:  Biomacromolecules       Date:  2013-06-05       Impact factor: 6.988

  2 in total

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