BACKGROUND: Loss of E-cadherin-catenin mediated adhesion is known to play a major role in tumour progression in many human carcinomas. MATERIALS AND METHODS: By means of immunohistochemistry, we have investigated the expression of E-cadherin, beta-catenin and p120ctn in 102 transitional cell bladder carcinomas (TCCs) and statistically analysed these expressions with known clinicopathological parameters and patient survival. RESULTS: Abnormal expression of E-cadherin, beta-catenin and p120ctn was associated with high grade and high stage of TCCs (p < 0.001). Abnormal beta-catenin expression demonstrated a statistically significant correlation with poor patient survival (p = 0.03) while abnormal E-cadherin expression was associated with poor survival in patients with muscle invasive TCCs (p = 0.025). However, in multivariate statistical analysis a suggestive association with poor survival was observed only for E-cadherin (p = 0.06). Simultaneous abnormal expression of all the molecules demonstrated an association of suggestive significance with poor patient survival (p = 0.07). CONCLUSION: E-cadherin expression may be a useful prognostic marker in patients with invasive TCCs.
BACKGROUND: Loss of E-cadherin-catenin mediated adhesion is known to play a major role in tumour progression in many humancarcinomas. MATERIALS AND METHODS: By means of immunohistochemistry, we have investigated the expression of E-cadherin, beta-catenin and p120ctn in 102 transitional cell bladder carcinomas (TCCs) and statistically analysed these expressions with known clinicopathological parameters and patient survival. RESULTS: Abnormal expression of E-cadherin, beta-catenin and p120ctn was associated with high grade and high stage of TCCs (p < 0.001). Abnormal beta-catenin expression demonstrated a statistically significant correlation with poor patient survival (p = 0.03) while abnormal E-cadherin expression was associated with poor survival in patients with muscle invasive TCCs (p = 0.025). However, in multivariate statistical analysis a suggestive association with poor survival was observed only for E-cadherin (p = 0.06). Simultaneous abnormal expression of all the molecules demonstrated an association of suggestive significance with poor patient survival (p = 0.07). CONCLUSION:E-cadherin expression may be a useful prognostic marker in patients with invasive TCCs.
Authors: Emhonta Johnson; Darcie D Seachrist; Carlos M DeLeon-Rodriguez; Kristen L Lozada; John Miedler; Fadi W Abdul-Karim; Ruth A Keri Journal: J Biol Chem Date: 2010-07-01 Impact factor: 5.157
Authors: I Ahmad; J P Morton; L B Singh; S M Radulescu; R A Ridgway; S Patel; J Woodgett; D J Winton; M M Taketo; X-R Wu; H Y Leung; O J Sansom Journal: Oncogene Date: 2010-09-06 Impact factor: 9.867
Authors: María Victoria Mencucci; Lara Lapyckyj; Marina Rosso; María José Besso; Denise Belgorosky; Mariana Isola; Silvia Vanzulli; Catalina Lodillinsky; Ana María Eiján; Juan Carlos Tejerizo; Matías Ignacio Gonzalez; María Ercilia Zubieta; Mónica Hebe Vazquez-Levin Journal: Front Oncol Date: 2020-03-27 Impact factor: 6.244