H Läderach1, W Straub. 1. Department of Internal Medicine, University of Berne, Inselspital, Berne, Switzerland.
Abstract
BACKGROUND: The aim of the present study was to measure the influence of a defined period of standardised voluntary hyperventilation on the levels of glucose, free fatty acids and several glucose regulating hormones in healthy volunteers. STUDY DESIGN:Eight healthy male subjects were submitted to 20 minutes of controlled hyperventilation and blood levels of glucose, free fatty acids, insulin, glucagon, cortisol, catecholamines and pCO2 were measured before, immediately after and 20 minutes after the end of the hyperventilation period. RESULTS: The hyperventilation led to a significant increase in all above mentioned parameters, except for glucose, where the effect was negligible. CONCLUSIONS: In view of the frequency of accompanying hyperventilation in a great variety of diseases and notably in some intensive care patients we postulate that pitfalls in the interpretation of plasma values of substances involved in glucose metabolism may be avoided by simultaneous determination of arterial pCO2.
RCT Entities:
BACKGROUND: The aim of the present study was to measure the influence of a defined period of standardised voluntary hyperventilation on the levels of glucose, free fatty acids and several glucose regulating hormones in healthy volunteers. STUDY DESIGN: Eight healthy male subjects were submitted to 20 minutes of controlled hyperventilation and blood levels of glucose, free fatty acids, insulin, glucagon, cortisol, catecholamines and pCO2 were measured before, immediately after and 20 minutes after the end of the hyperventilation period. RESULTS: The hyperventilation led to a significant increase in all above mentioned parameters, except for glucose, where the effect was negligible. CONCLUSIONS: In view of the frequency of accompanying hyperventilation in a great variety of diseases and notably in some intensive care patients we postulate that pitfalls in the interpretation of plasma values of substances involved in glucose metabolism may be avoided by simultaneous determination of arterial pCO2.
Authors: Matthijs Kox; Lucas T van Eijk; Jelle Zwaag; Joanne van den Wildenberg; Fred C G J Sweep; Johannes G van der Hoeven; Peter Pickkers Journal: Proc Natl Acad Sci U S A Date: 2014-05-05 Impact factor: 11.205