| Literature DB >> 11205146 |
J Strelau1, M Böttner, P Lingor, C Suter-Crazzolara, D Galter, J Jaszai, A Sullivan, A Schober, K Krieglstein, K Unsicker.
Abstract
We have cloned, expressed, and raised antibodies against a novel member of the TGF-beta superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-beta superfamily and does not belong to one of the known TGF-beta subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.Entities:
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Year: 2000 PMID： 11205146 DOI： 10.1007/978-3-7091-6301-6_18
Source DB: PubMed Journal: J Neural Transm Suppl ISSN： 0303-6995