Frequency and Markov chain analysis of amino acid sequences of mouse p53.

The amino acid sequence of mouse p53 was measured according to two- and three-amino-acid sequences. The measured frequency and probability were compared with predicted frequency and probability. Of 389 two-amino-acid sequences in mouse p53,85 (21.851%) and 27 (6.941%) sequences can be explained by the predicted frequency and probability according to a purelyrandom mechanism. Of 188 non-appearing two-amino-acid sequences in mouse p53, 86 (45.745%) and 32 (17.021%) can be explained by the predicted frequency and probability according to a purely random mechanism; no more than two-amino-acid sequences in mouse p53 can be explained by a purely random mechanism.