| Literature DB >> 11200287 |
K N Tiwari1, A T Shortnacy-Fowler, L Cappellacci, W R Waud, W B Parker, J A Montgomery, J A Secrist.
Abstract
Four 5-substituted (chloro, fluoro, bromo, methyl) 1-(4-thio-beta-D-arabinofuranosyl)cytosines and their alpha anomers were synthesized by a facile route in high yields. All of these nucleosides were evaluated for cytotoxicity against a panel of human tumor cell lines in vitro. Only 5-fluoro-1-(4-thio-beta-D-arabinofuranosyl)cytosine was found to be highly cytotoxic in all the cell lines and was further evaluated in vivo.Entities:
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Year: 2000 PMID： 11200287 DOI： 10.1080/15257770008045474
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381