Literature DB >> 11200266

Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position.

A V Kachalova1, T S Zatsepin, E A Romanova, D A Stetsenko, M J Gait, T S Oretskaya.   

Abstract

Chemical syntheses of 2'-O-(allyloxycarbonyl)methyladenosine, 2'-O-(methoxycarbonyl)methyladenosine and 2'-O-(2,3-dibenzoyloxy)propyluridine 3'-2-cyanoethyl-N,N-diisopropyl phosphoramidite building blocks are described. These monomers were used successfully to incorporate carboxylic acid, 1,2-diol and aldehyde functionalities into synthetic oligonucleotides.

Entities:  

Mesh:

Substances:

Year:  2000        PMID: 11200266     DOI: 10.1080/15257770008045453

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  Oligonucleotides with 2'-O-carboxymethyl group: synthesis and 2'-conjugation via amide bond formation on solid phase.

Authors:  Anna Kachalova; Eugeny Zubin; Dmitry Stetsenko; Michael Gait; Tatiana Oretskaya
Journal:  Org Biomol Chem       Date:  2004-09-03       Impact factor: 3.876

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.