Literature DB >> 11199140

Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea.

A Rojas, M Bah, J I Rojas, D M Gutiérrez.   

Abstract

Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of isolated guinea pig ileum. Contractions induced by histamine, acetylcholine, BaCl2 and KCl on the ileum were also significantly blocked by this monoterpene glucoside, which suggests that this compound might be interfering with calcium influx into the smooth muscle cells.

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Year:  2000        PMID： 11199140     DOI： 10.1055/s-2000-9774

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

1.  Application of quantitative 1H-NMR method to determination of gentiopicroside in Gentianae radix and Gentianae scabrae radix.

Authors:  Rie Tanaka; Yuko Hasebe; Akito Nagatsu
Journal:  J Nat Med       Date:  2014-04-01       Impact factor: 2.343

2.  Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice.

Authors:  Chang-Hong Wang; Zheng-Tao Wang; S W Annie Bligh; Kenneth N White; Christopher J Branford White
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Jul-Sep       Impact factor: 2.441

Review 3.  Gentians, natural remedies for future of visceral pain control; an ethnopharmacological review with an in silico approach.

Authors:  Ardalan Pasdaran; Daniela Butovska; Philip Kerr; Zheko Naychov; Ina Aneva; Ekaterina Kozuharova
Journal:  Biol Futur       Date:  2022-03-23

Review 4.  Treatment of Gastrointestinal Disorders-Plants and Potential Mechanisms of Action of Their Constituents.

Authors:  Szilvia Czigle; Silvia Bittner Fialová; Jaroslav Tóth; Pavel Mučaji; Milan Nagy
Journal:  Molecules       Date:  2022-04-30       Impact factor: 4.927

5.  Microbial biotransformation of gentiopicroside by the endophytic fungus Penicillium crustosum 2T01Y01.

Authors:  Wen-Liang Zeng; Wan-Kui Li; Han Han; Yan-Yan Tao; Li Yang; Zheng-Tao Wang; Kai-Xian Chen
Journal:  Appl Environ Microbiol       Date:  2013-10-18       Impact factor: 4.792

6.  Preparative Separation and Purification of Four Glycosides from Gentianae radix by High-Speed Counter-Current Chromatography and Comparison of Their Anti-NO Production Effects.

Authors:  Bao Chen; Yinghua Peng; Xinhui Wang; Zhiman Li; Yinshi Sun
Journal:  Molecules       Date:  2017-11-17       Impact factor: 4.411

7.  Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta.

Authors:  Shangping Xing; Feifei Nong; Jialiang Qin; Huicai Huang; Ruoting Zhan; Weiwen Chen
Journal:  Biomed Res Int       Date:  2021-05-14       Impact factor: 3.411

8.  Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts.

Authors:  Rushendhiran Kesavan; Uma Rani Potunuru; Branislav Nastasijević; Avaneesh T; Gordana Joksić; Madhulika Dixit
Journal:  PLoS One       Date:  2013-04-18       Impact factor: 3.240

9.  Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies.

Authors:  Laura Guedes; Pedro B P S Reis; Miguel Machuqueiro; Asma Ressaissi; Rita Pacheco; Maria Luísa Serralheiro
Journal:  Molecules       Date:  2019-10-22       Impact factor: 4.411
  9 in total

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