Literature DB >> 11199123

Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis.

R L Huang1, C C Chen, H L Huang, C G Chang, C F Chen, C Chang, M T Hsieh.   

Abstract

By using an HBV-producing cell line (MS-G2) in vitro culture system, we found that wogonin isolated from Scutellaria baicalensis can suppress HBV surface antigen production (P < 0.001) without evidence of cytotoxicity. By assaying the endogenous HBV DNA polymerase activity, we found that both the relaxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for the treatment of human HBV infection.

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Year:  2000        PMID： 11199123     DOI： 10.1055/s-2000-9775

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  18 in total

1.  Vascular relaxation induced by Eucommiae Ulmoides Oliv. and its compounds Oroxylin A and wogonin: implications on their cytoprotection action.

Authors:  Mary Akinyi; Xiu Mei Gao; Yu Hong Li; Bing Yao Wang; Er Wei Liu; Li Juan Chai; Abdulai JawoBah; Guan Wei Fan
Journal:  Int J Clin Exp Med       Date:  2014-10-15

Review 2.  Natural products as promising drug candidates for the treatment of hepatitis B and C.

Authors:  Carolin Wohlfarth; Thomas Efferth
Journal:  Acta Pharmacol Sin       Date:  2008-12-08       Impact factor: 6.150

3.  The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells.

Authors:  Daisuke Sato; Seiji Kondo; Kazunaga Yazawa; Yoshiki Mukudai; Chunnan Li; Takaaki Kamatani; Hideyuki Katsuta; Yasuto Yoshihama; Tatsuo Shirota; Satoru Shintani
Journal:  Mol Clin Oncol       Date:  2012-08-23

4.  Potent natural products and herbal medicines for treating liver fibrosis.

Authors:  Shao-Ru Chen; Xiu-Ping Chen; Jin-Jian Lu; Ying Wang; Yi-Tao Wang
Journal:  Chin Med       Date:  2015-04-15       Impact factor: 5.455

5.  Effects of baicalein on IL-1β-induced inflammation and apoptosis in rat articular chondrocytes.

Authors:  Yue Li; Jinglu Wang; Xiaopeng Song; Hui Bai; Tianwen Ma; Zhiheng Zhang; Xinran Li; Renli Jiang; Guanying Wang; Xiaojing Fan; Xu Liu; Li Gao
Journal:  Oncotarget       Date:  2017-10-11

6.  Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways.

Authors:  Ying Chu; Xiaowen Lv; Longfeng Zhang; Xingli Fu; Siwei Song; Airong Su; Deyan Chen; Lianhong Xu; Yongfang Wang; Zhiwei Wu; Zhihua Yun
Journal:  BMC Microbiol       Date:  2020-07-28       Impact factor: 3.605

7.  Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats.

Authors:  Chin-Tsung Ting; Yung-Yi Cheng; Tung-Hu Tsai
Journal:  Molecules       Date:  2017-06-22       Impact factor: 4.411

Review 8.  A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis.

Authors:  Zi-Long Wang; Shuang Wang; Yi Kuang; Zhi-Min Hu; Xue Qiao; Min Ye
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503

Review 9.  The Therapeutic Potential of Wogonin Observed in Preclinical Studies.

Authors:  Javad Sharifi-Rad; Jesús Herrera-Bravo; Luis A Salazar; Shabnum Shaheen; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Muhammad Imran; Ali Imran; Luísa Custódio; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C Cho
Journal:  Evid Based Complement Alternat Med       Date:  2021-06-15       Impact factor: 2.629

10.  Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses.

Authors:  Mann-Jen Hour; Su-Hua Huang; Ching-Yao Chang; Yen-Kuan Lin; Ching-Ying Wang; Yuan-Shiun Chang; Cheng-Wen Lin
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-20       Impact factor: 2.629
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