Literature DB >> 11197530

Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).

G J Kops1, B M Burgering.   

Abstract

Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.

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Year:  2000        PMID： 11197530      PMCID： PMC1468172          DOI： 10.1046/j.1469-7580.2000.19740571.x

Source DB:  PubMed          Journal:  J Anat        ISSN： 0021-8782            Impact factor:   2.610


  23 in total

1.  Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

Authors:  P C van Weeren; K M de Bruyn; A M de Vries-Smits; J van Lint; B M Burgering
Journal:  J Biol Chem       Date:  1998-05-22       Impact factor: 5.157

2.  Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation.

Authors:  A D Kohn; S A Summers; M J Birnbaum; R A Roth
Journal:  J Biol Chem       Date:  1996-12-06       Impact factor: 5.157

3.  Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).

Authors:  A Borkhardt; R Repp; O A Haas; T Leis; J Harbott; J Kreuder; J Hammermann; T Henn; F Lampert
Journal:  Oncogene       Date:  1997-01-16       Impact factor: 9.867

4.  Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades.

Authors:  J Deprez; D Vertommen; D R Alessi; L Hue; M H Rider
Journal:  J Biol Chem       Date:  1997-07-11       Impact factor: 5.157

5.  4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.

Authors:  A C Gingras; S G Kennedy; M A O'Leary; N Sonenberg; N Hay
Journal:  Genes Dev       Date:  1998-02-15       Impact factor: 11.361

6.  Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence.

Authors:  S B Cichy; S Uddin; A Danilkovich; S Guo; A Klippel; T G Unterman
Journal:  J Biol Chem       Date:  1998-03-13       Impact factor: 5.157

7.  The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.

Authors:  S Ogg; S Paradis; S Gottlieb; G I Patterson; L Lee; H A Tissenbaum; G Ruvkun
Journal:  Nature       Date:  1997-10-30       Impact factor: 49.962

8.  Regulation of neuronal survival by the serine-threonine protein kinase Akt.

Authors:  H Dudek; S R Datta; T F Franke; M J Birnbaum; R Yao; G M Cooper; R A Segal; D R Kaplan; M E Greenberg
Journal:  Science       Date:  1997-01-31       Impact factor: 47.728

9.  Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.

Authors:  S Dimmeler; I Fleming; B Fisslthaler; C Hermann; R Busse; A M Zeiher
Journal:  Nature       Date:  1999-06-10       Impact factor: 49.962

10.  The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.

Authors:  J E Sublett; I S Jeon; D N Shapiro
Journal:  Oncogene       Date:  1995-08-03       Impact factor: 9.867
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  17 in total

Review 1.  Protein kinases: emerging therapeutic targets in chronic lymphocytic leukemia.

Authors:  Kumudha Balakrishnan; Varsha Gandhi
Journal:  Expert Opin Investig Drugs       Date:  2012-03-09       Impact factor: 6.206

Review 2.  Forkhead family transcription factor FoxO and neural differentiation.

Authors:  Qiang Wen; Haitao Wang; Peter J Little; Remi Quirion; Wenhua Zheng
Journal:  Neurogenetics       Date:  2012-03-28       Impact factor: 2.660

3.  Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1.

Authors:  Lisa M Kennedy; Steven C D L Pham; Alla Grishok
Journal:  Cell Rep       Date:  2013-08-29       Impact factor: 9.423

4.  Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy.

Authors:  Sandro Goruppi; Joseph V Bonventre; John M Kyriakis
Journal:  EMBO J       Date:  2002-10-15       Impact factor: 11.598

Review 5.  Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand.

Authors:  Nor Saadah M Azahri; Mary M Kavurma
Journal:  Cell Mol Life Sci       Date:  2013-01-18       Impact factor: 9.261

6.  Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.

Authors:  Sreelatha Gopinath; Rama Rao Malla; Christopher S Gondi; Kiranmai Alapati; Daniel Fassett; Jeffrey D Klopfenstein; Dzung H Dinh; Meena Gujrati; Jasti S Rao
Journal:  PLoS One       Date:  2010-07-22       Impact factor: 3.240

7.  Conditional deletion of Pten causes bronchiolar hyperplasia.

Authors:  Vrushank Davé; Susan E Wert; Tiffany Tanner; Angela R Thitoff; Dave E Loudy; Jeffrey A Whitsett
Journal:  Am J Respir Cell Mol Biol       Date:  2007-10-05       Impact factor: 6.914

Review 8.  Targeting prostate cancer based on signal transduction and cell cycle pathways.

Authors:  John T Lee; Brian D Lehmann; David M Terrian; William H Chappell; Franca Stivala; Massimo Libra; Alberto M Martelli; Linda S Steelman; James A McCubrey
Journal:  Cell Cycle       Date:  2008-06-16       Impact factor: 4.534

9.  Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor.

Authors:  Saghi Ghaffari; Zainab Jagani; Claire Kitidis; Harvey F Lodish; Roya Khosravi-Far
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-15       Impact factor: 11.205

10.  CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection.

Authors:  Zachary R Shaheen; Aaron Naatz; John A Corbett
Journal:  J Immunol       Date:  2015-09-25       Impact factor: 5.422
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