Literature DB >> 11197364

Multidrug-resistance protein 1 in focal cortical dysplasia.

S M Sisodiya, W R Lin, M V Squier, M Thom.   

Abstract

Drug resistance in epilepsy is poorly understood. We used routine immunohistochemistry to assess overexpression of a multidrug-resistance protein in dysplastic neurons, glia, and around vessels in surgically resected epileptogenic human brain tissue. We showed non-tumoral overexpression of this multidrug-resistance protein, which might contribute to drug resistance in epilepsy caused by focal cortical dysplasia.

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Year:  2001        PMID： 11197364     DOI： 10.1016/s0140-6736(00)03573-x

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  15 in total

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6.  Neuronal and glial expression of the multidrug resistance gene product in an experimental epilepsy model.

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7.  Upregulation of Multidrug Resistance Transporters in the Epileptic Brain.

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Review 9.  Various pharmacogenetic aspects of antiepileptic drug therapy: a review.

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10.  Significance of MDR1 and multiple drug resistance in refractory human epileptic brain.

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