| Literature DB >> 11197361 |
H Liu, A Ruskon-Fourmestraux, A Lavergne-Slove, H Ye, T Molina, Y Bouhnik, R A Hamoudi, T C Diss, A Dogan, F Megraud, J C Rambaud, M Q Du, P G Isaacson.
Abstract
20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the AP12 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The AP12-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).Entities:
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Year: 2001 PMID： 11197361 DOI： 10.1016/S0140-6736(00)03571-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321