Literature DB >> 11197332

Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study.

M Komoda1, H Kakuta, H Takahashi, Y Fujimoto, S Kadoya, F Kato, Y Hashimoto.   

Abstract

2-(2,6-Diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (2: PIQ-22) was found to be a potent and specific inhibitor of puromycin-sensitive aminopeptidase (PSA). Lineweaver-Burk plot analysis showed that PSA is inhibited by PIQ-22 in a non-competitive manner. Structure -activity relationship studies indicated that tautomerism of the imidobenzoylketone group in the cyclic imide moiety of the PIQ-22 skeleton is important for the inhibitory activity.

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Year:  2001        PMID： 11197332     DOI： 10.1016/s0968-0896(00)00231-5

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  10 in total

1.  The catalytic and protein-protein interaction domains are required for APM1 function.

Authors:  Fazeeda N Hosein; Anindita Bandyopadhyay; Wendy Ann Peer; Angus S Murphy
Journal:  Plant Physiol       Date:  2010-02-12       Impact factor: 8.340

2.  Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis.

Authors:  Angus S Murphy; Karen R Hoogner; Wendy Ann Peer; Lincoln Taiz
Journal:  Plant Physiol       Date:  2002-03       Impact factor: 8.340

3.  Complementary regioselectivity in Rh(III)-catalyzed insertions of potassium vinyltrifluoroborate via C-H activation: preparation and use of 4-trifluoroboratotetrahydroisoquinolones.

Authors:  Marc Presset; Daniel Oehlrich; Frederik Rombouts; Gary A Molander
Journal:  Org Lett       Date:  2013-03-15       Impact factor: 6.005

4.  Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.

Authors:  Fiona M Menzies; Raphael Hourez; Sara Imarisio; Marcel Raspe; Oana Sadiq; Dhia Chandraratna; Cahir O'Kane; Kenneth L Rock; Eric Reits; Alfred L Goldberg; David C Rubinsztein
Journal:  Hum Mol Genet       Date:  2010-09-09       Impact factor: 6.150

5.  Variation in expression and protein localization of the PIN family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin transport in Arabidopsis thaliana.

Authors:  Wendy Ann Peer; Anindita Bandyopadhyay; Joshua J Blakeslee; Srinivas N Makam; Rujin J Chen; Patrick H Masson; Angus S Murphy
Journal:  Plant Cell       Date:  2004-06-18       Impact factor: 11.277

Review 6.  The role of multifunctional M1 metallopeptidases in cell cycle progression.

Authors:  Wendy Ann Peer
Journal:  Ann Bot       Date:  2011-01-21       Impact factor: 4.357

7.  Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia.

Authors:  Peter Röhnert; Werner Schmidt; Patrick Emmerlich; Alexander Goihl; Sabine Wrenger; Ute Bank; Karsten Nordhoff; Michael Täger; Siegfried Ansorge; Dirk Reinhold; Frank Striggow
Journal:  J Neuroinflammation       Date:  2012-02-28       Impact factor: 8.322

Review 8.  Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Authors:  Brigitte Bauvois; Daniel Dauzonne
Journal:  Med Res Rev       Date:  2006-01       Impact factor: 12.944

9.  A puromycin-sensitive aminopeptidase is essential for meiosis in Arabidopsis thaliana.

Authors:  Eugenio Sánchez-Morán; Gareth H Jones; F Christopher H Franklin; Juan Luis Santos
Journal:  Plant Cell       Date:  2004-11       Impact factor: 11.277

10.  Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.

Authors:  Mingqun Lin; Hongyan Liu; Qingming Xiong; Hua Niu; Zhihui Cheng; Akitsugu Yamamoto; Yasuko Rikihisa
Journal:  Autophagy       Date:  2016-08-19       Impact factor: 16.016
  10 in total

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