| Literature DB >> 11197307 |
T C van der Pouw Kraan1, A van Veen, L C Boeije, S A van Tuyl, E R de Groot, S O Stapel, A Bakker, C L Verweij, L A Aarden, J S van der Zee.
Abstract
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma.Entities:
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Year: 1999 PMID： 11197307 DOI： 10.1038/sj.gene.6363630
Source DB: PubMed Journal: Genes Immun ISSN： 1466-4879 Impact factor: 2.676