| Literature DB >> 11197205 |
Abstract
A chemokine, stromal cell-derived factor/pre-B-cell growth-stimulating factor (SDF-1/PBSF), and its primary physiologic receptor, CXC chemokine receptor 4 (CXCR4), are essential for B-lymphocyte production and colonization of bone marrow by myeloid lineage progenitors during embryogenesis. Moreover, CXCR4 is an autonomous cell essential for long-term lymphoid and myeloid reconstitution in adult bone marrow. Upregulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.Entities:
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Year: 2000 PMID: 11197205
Source DB: PubMed Journal: Int J Hematol ISSN: 0925-5710 Impact factor: 2.490