Literature DB >> 1119714

Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys.

E S Munson, W K Tucker, B Ausinsch, M H Malagodi.   

Abstract

The central nervous system toxicities of etidocaine, bupivacaine, and lidocaine were studied during constant-rate intravenous infusions in rhesus monkeys. Comparison of drug effects was achieved by determining the drug dosages and arterial plasma concentrations that induced electrical seizure activity. The central nervous system toxicity of etidocaine was similar to that of bupivacaine. The toxicity of each was four times greater than that of lidocaine. Since the drug infusion rates were proportional to anesthetic potencies in clinical usage, the therapeutic-toxic ratios of these three drugs are similar.

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Year:  1975        PMID： 1119714     DOI： 10.1097/00000542-197504000-00018

Source DB:  PubMed          Journal:  Anesthesiology        ISSN： 0003-3022            Impact factor:   7.892


  10 in total

1.  Topical bupivacaine and etidocaine analgesia following fallopian tube banding.

Authors:  R McKenzie; P Phitayakorn; N T Uy; J Chalasani; B M Melnick; R L Kennedy; A F Vicinie
Journal:  Can J Anaesth       Date:  1989-09       Impact factor: 5.063

Review 2.  Clinical pharmacokinetics of local anaesthetics.

Authors:  G T Tucker; L E Mather
Journal:  Clin Pharmacokinet       Date:  1979 Jul-Aug       Impact factor: 6.447

3.  Etidocaine--a long-acting anesthetic agent. Review of the literature.

Authors:  D G Garcia
Journal:  Anesth Prog       Date:  1982 Jan-Feb

4.  Regional Anesthesia for Dentistry and Orofacial Surgery in Rhesus Macaques (Macaca mulatta).

Authors:  Robyn M Engel; Marvin L Thomas; Ron E Banks
Journal:  J Am Assoc Lab Anim Sci       Date:  2019-01-10       Impact factor: 1.232

5.  A comparison of etidocaine and lidocaine in epidural analgesia for surgery.

Authors:  A Raksamani; G Edelist
Journal:  Can Anaesth Soc J       Date:  1977-01

6.  Absorption of bupivacaine after topical application to the oropharynx.

Authors:  J C Phero; P Prithvi Raj; D Knarr; P Turner; D D Denson; E Vigdorth; H H Edstrom
Journal:  Anesth Prog       Date:  1987 Sep-Oct

7.  Local anaesthetic actions of cocaine: effects on excitatory and inhibitory synaptic responses in the hippocampus in vitro.

Authors:  T V Dunwiddie; W R Proctor; J Tyma
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

8.  A fully implanted drug delivery system for peripheral nerve blocks in behaving animals.

Authors:  Eric A Pohlmeyer; Luke R Jordon; Peter Kim; Lee E Miller
Journal:  J Neurosci Methods       Date:  2009-06-12       Impact factor: 2.390

9.  Thoracic epidural catheter for postoperative pain control following an ineffective transversus abdominis plane block using liposome bupivacaine.

Authors:  Brian D Terrien; David Espinoza; Charles C Stehman; Gabriel A Rodriguez; Nicholas C Connolly
Journal:  J Pain Res       Date:  2017-01-16       Impact factor: 3.133

Review 10.  Chiral Aspects of Local Anesthetics.

Authors:  Ružena Čižmáriková; Jozef Čižmárik; Jindra Valentová; Ladislav Habala; Mário Markuliak
Journal:  Molecules       Date:  2020-06-12       Impact factor: 4.411
  10 in total

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