Literature DB >> 11196717

A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a.

J Eskdale1, R L Turestkaya, C Armstrong, D V Kuprash, S A Nedospasov, G Gallagher.   

Abstract

We provide characterization of a highly polymorphic dinucleotide repeat in the human TNF-receptor 1 gene (TNFR1, TNFRp55, CD120a). We have observed 11 alleles at this locus in individuals from the West of Scotland. In a panel of healthy, unrelated individuals from the West of Scotland (n = 143), the overall heterozygosity was 68%, indicating the potential usefulness of these markers in immunogenetic studies.

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Year:  2000        PMID： 11196717     DOI： 10.1038/sj.gene.6363663

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  2 in total

1.  The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.

Authors:  I Aksentijevich; J Galon; M Soares; E Mansfield; K Hull; H H Oh; R Goldbach-Mansky; J Dean; B Athreya; A J Reginato; M Henrickson; B Pons-Estel; J J O'Shea; D L Kastner
Journal:  Am J Hum Genet       Date:  2001-07-06       Impact factor: 11.025

2.  The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis.

Authors:  Dieter E Jenne; Peer M Aries; Simon Einwächter; Amer D Akkad; Stefan Wieczorek; Peter Lamprecht; Wolfgang L Gross
Journal:  Ann Rheum Dis       Date:  2007-09       Impact factor: 19.103
  2 in total

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