Literature DB >> 11196276

An infant with homozygous hemoglobin D-Iran.

C D Thornburg1, S A Zimmerman, W H Schultz, R E Ware.   

Abstract

Hemoglobin D-Iran (Hb D-Iran, beta 22 Glu-->Gln) is a beta-chain variant that was first described in 1973. Hb D-Iran in combination with normal Hb A (Hb D-Iran trait) is a benign condition. Hb D-Iran has also been described in combination with sickle hemoglobin and beta thalassemia, but never as a homozygous mutation. The authors describe a case of homozygous Hb D-Iran in an infant of Pakistani descent. The hematologic values, hemoglobin electrophoresis, peripheral blood smear, and clinical course to date suggest that homozygous Hb D-Iran is a relatively benign condition with mild microcytic anemia, poikilocytosis, and minimal hemolysis.

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Year:  2001        PMID： 11196276     DOI： 10.1097/00043426-200101000-00017

Source DB:  PubMed          Journal:  J Pediatr Hematol Oncol        ISSN： 1077-4114            Impact factor:   1.289


  2 in total

1.  Serendipity: A Rare Discovery of Haemoglobin D-Iran in An Indian Female During Routine Antenatal Screening for β-Thalassemia.

Authors:  Rittu Surjit Chandel; Abhishek Roy; Leela Gul Abichandani
Journal:  J Clin Diagn Res       Date:  2015-07-01

2.  Compound heterozygote of Hb DIran [HBB: c.67G>C, β 22(B4) Glu>Gln] with β0-thalassemia [cds 41/42 (-CTTT)] from Eastern India.

Authors:  Pradeep Kumar Mohanty; Satyabrata Meher; Snehadhini Dehury; Subhra Bhattacharya; Kishalaya Das; Siris Patel; Biswanath Sarkar
Journal:  Rev Bras Hematol Hemoter       Date:  2017-12-01
  2 in total

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