Literature DB >> 111954

Disodium cromoglycate: a novel gastric antiulcer agent?

C W Ogle, H K Lau.   

Abstract

The influence of oral pretreatment with disodium cromoglycate (2.5 or 5 mg/kg X 9 doses) on the 4-h gastric effects of i.p. injected reserpine (5 mg/kg) was examined in rats. Disodium cromoglycate markedly prevented reserpine-induced ulceration, mucosal mast cell degranulation and superficial mucosal microcirculatory changes in the glandular portion of the stomach wall. These interesting results points to the possibility that disodium cromoglycate may also have gastric antiulcer effects in man.

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Year:  1979        PMID： 111954     DOI： 10.1016/0014-2999(79)90117-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  The influence of peripheral or central administration of ondansetron on stress-induced gastric ulceration in rats.

Authors:  C W Ogle; S C Hui
Journal:  Experientia       Date:  1995-08-16

2.  Ventricular histamine concentrations and mast cell counts in the rat heart during acute ischaemia.

Authors:  S Dai; C W Ogle
Journal:  Agents Actions       Date:  1990-03

3.  Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats.

Authors:  L R Fitzpatrick; D L Decktor
Journal:  Agents Actions       Date:  1991-07

4.  Inhibition of gastric acid secretion with a mast cell stabiliser, FPL-52694.

Authors:  H A Davies; J Rhodes; M Thomas
Journal:  Br J Clin Pharmacol       Date:  1981-01       Impact factor: 4.335

5.  Sulphasalazine and experimental stress ulcers.

Authors:  C W Ogle; C H Cho; S Dai
Journal:  Agents Actions       Date:  1985-12

6.  Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats.

Authors:  Vivek Srivastava; A H M Viswanathaswamy; Govind Mohan
Journal:  Indian J Pharmacol       Date:  2010-06       Impact factor: 1.200

7.  Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats.

Authors:  K Takeuchi; Y Ishihara; H Kunimi; S Okabe
Journal:  Agents Actions       Date:  1984-06

8.  Ethanol-induced acute gastric injury in mast cell-deficient and congenic normal mice. Evidence that mast cells can augment the area of damage.

Authors:  S J Galli; B K Wershil; R Bose; P A Walker; S Szabo
Journal:  Am J Pathol       Date:  1987-07       Impact factor: 4.307

Review 9.  Histidine decarboxylase inhibition: a novel approach towards the development of an effective and safe gastric anti-ulcer drug.

Authors:  N S Parmar; G Hennings; O P Gulati
Journal:  Agents Actions       Date:  1984-12

10.  Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats.

Authors:  Y Tabuchi; K Kawarabayashi; K Furuhama
Journal:  Agents Actions       Date:  1994-03
  10 in total

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