Literature DB >> 11195043

Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes.

J A Duncan1, J W Scholey, J A Miller.   

Abstract

Many studies have attempted to relate genetic variants of components of the renin-angiotensin system to complex diseases such as essential hypertension, cardiovascular disease and progressive renal failure. The angiotensin II type 1 receptor (AT1R) gene is an important example of this approach. Many polymorphisms of the AT1R gene have been identified, but the A1166-->C polymorphism has been the most extensively studied. The physiological significance of this polymorphism is uncertain because of its location in the 3'-untranslated region of the gene. The present review summarizes association studies of the AT1R gene, focusing on clinical end-points and physiological responses.

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Year:  2001        PMID： 11195043     DOI： 10.1097/00041552-200101000-00017

Source DB:  PubMed          Journal:  Curr Opin Nephrol Hypertens        ISSN： 1062-4821            Impact factor:   2.894


  14 in total

1.  Catalog of 178 variations in the Japanese population among eight human genes encoding G protein-coupled receptors (GPCRs).

Authors:  Susumu Saito; Aritoshi Iida; Akihiro Sekine; Saori Kawauchi; Shoko Higuchi; Chie Ogawa; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2003-08-30       Impact factor: 3.172

2.  A1166C variant of angiotensin II type 1 receptor gene is associated with severe hypertension in pregnancy independently of T235 variant of angiotensinogen gene.

Authors:  Gen Kobashi; Akira Hata; Kaori Ohta; Hideto Yamada; Emi Hirayama Kato; Hisanori Minakami; Seiichiro Fujimoto; Kiyotaro Kondo
Journal:  J Hum Genet       Date:  2004-03-23       Impact factor: 3.172

Review 3.  International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].

Authors:  Sadashiva S Karnik; Hamiyet Unal; Jacqueline R Kemp; Kalyan C Tirupula; Satoru Eguchi; Patrick M L Vanderheyden; Walter G Thomas
Journal:  Pharmacol Rev       Date:  2015-10       Impact factor: 25.468

4.  Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults.

Authors:  Lauren E Salminen; Peter R Schofield; Kerrie D Pierce; Thomas E Conturo; David F Tate; Elizabeth M Lane; Jodi M Heaps; Jacob D Bolzenius; Laurie M Baker; Erbil Akbudak; Robert H Paul
Journal:  Age (Dordr)       Date:  2014-07-01

Review 5.  Renin-angiotensin-aldosterone system: fundamental aspects and clinical implications in renal and cardiovascular disorders.

Authors:  Mark A Perazella; John F Setaro
Journal:  J Nucl Cardiol       Date:  2003 Mar-Apr       Impact factor: 5.952

6.  Association of angiotensin II type I and type II receptor genes polymorphisms with the presence of premature coronary disease and metabolic syndrome.

Authors:  Tarek A Abd El-Aziz; Randa H Mohamed; Noha A Rezk
Journal:  Mol Biol Rep       Date:  2014-01-03       Impact factor: 2.316

7.  Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits.

Authors:  M R Abdollahi; T R Gaunt; H E Syddall; C Cooper; D I W Phillips; S Ye; I N M Day
Journal:  J Med Genet       Date:  2005-05       Impact factor: 6.318

8.  Genetic polymorphisms and risk for acute renal failure in preterm neonates.

Authors:  Barna Vásárhelyi; Péter Tóth-Heyn; András Treszl; Tivadar Tulassay
Journal:  Pediatr Nephrol       Date:  2004-12-31       Impact factor: 3.714

9.  Angiotensin type 1 receptor resistance to blockade in the opossum proximal tubule cell due to variations in the binding pocket.

Authors:  Ravi Nistala; Bradley T Andresen; Lakshmi Pulakat; Alex Meuth; Catherine Sinak; Chirag Mandavia; Thomas Thekkumkara; Robert C Speth; Adam Whaley-Connell; James R Sowers
Journal:  Am J Physiol Renal Physiol       Date:  2013-02-06

10.  Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients.

Authors:  Katya Mokretar; Hristo Velinov; Arman Postadzhiyan; Margarita Apostolova
Journal:  Genet Test Mol Biomarkers       Date:  2015-12-15
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