OBJECTIVE: To test the hypothesis that continuous gastric infusion (CGI) is better tolerated than intermittent gastric bolus (IGB) in small very low birth weight (VLBW) infants. DESIGN: Two-center, prospective, randomized, unmasked clinical trial. PATIENTS: 28 VLBW infants (birth weight <1250 g). A strict feeding protocol was followed. INTERVENTION: Patients were randomized to IGB or CGI. MAIN OUTCOME MEASURES: Time to reach full feeds (160 cc/kg/d)(by design and real), daily weight, caloric intake, residual gastric volume and type of feeding (formula vs. human milk vs. both). RESULTS: Five infants failed to complete the study because of death (n = 4) or protocol violation (n = 1). The two groups did not differ by birth weight or gestational age; infants fed via IGB reached full feeds earlier (p = 0.03) and had less delay in reaching full feeds than infants fed via CGI. CONCLUSION: Contrary to our hypothesis, gravity IGB is more effective than CGI in improving feeding tolerance in small VLBW infants.
RCT Entities:
OBJECTIVE: To test the hypothesis that continuous gastric infusion (CGI) is better tolerated than intermittent gastric bolus (IGB) in small very low birth weight (VLBW) infants. DESIGN: Two-center, prospective, randomized, unmasked clinical trial. PATIENTS: 28 VLBW infants (birth weight <1250 g). A strict feeding protocol was followed. INTERVENTION: Patients were randomized to IGB or CGI. MAIN OUTCOME MEASURES: Time to reach full feeds (160 cc/kg/d)(by design and real), daily weight, caloric intake, residual gastric volume and type of feeding (formula vs. human milk vs. both). RESULTS: Five infants failed to complete the study because of death (n = 4) or protocol violation (n = 1). The two groups did not differ by birth weight or gestational age; infants fed via IGB reached full feeds earlier (p = 0.03) and had less delay in reaching full feeds than infants fed via CGI. CONCLUSION: Contrary to our hypothesis, gravity IGB is more effective than CGI in improving feeding tolerance in small VLBW infants.
Authors: Samer W El-Kadi; Agus Suryawan; Maria C Gazzaneo; Neeraj Srivastava; Renán A Orellana; Hanh V Nguyen; Gerald E Lobley; Teresa A Davis Journal: Am J Physiol Endocrinol Metab Date: 2012-01-03 Impact factor: 4.310
Authors: Samer W El-Kadi; Claire Boutry; Agus Suryawan; Maria C Gazzaneo; Renán A Orellana; Neeraj Srivastava; Hanh V Nguyen; Scot R Kimball; Marta L Fiorotto; Teresa A Davis Journal: Am J Clin Nutr Date: 2018-10-01 Impact factor: 7.045
Authors: Claire Boutry; Samer W El-Kadi; Agus Suryawan; Scott M Wheatley; Renán A Orellana; Scot R Kimball; Hanh V Nguyen; Teresa A Davis Journal: Am J Physiol Endocrinol Metab Date: 2013-07-09 Impact factor: 4.310
Authors: Samer W El-Kadi; María C Gazzaneo; Agus Suryawan; Renán A Orellana; Roberto Murgas Torrazza; Neeraj Srivastava; Scot R Kimball; Hanh V Nguyen; Marta L Fiorotto; Teresa A Davis Journal: Pediatr Res Date: 2013-06-04 Impact factor: 3.756