Literature DB >> 11194197

The significance of CD44 variants expression in colorectal cancer and its regional lymph nodes.

S Y Chun1, O S Bae, J B Kim.   

Abstract

CD44 is a cell adhesion molecule with numerous isoforms created by mRNA alternative splicing. Expression of CD44 variants has been suggested to play a potential role in tumor progression and metastasis. We designed primers CD44V, CD44V6/7, CD44R1 and CD44V6-10 to analyze and compare the roles of each CD44 variants. Expressions of CD44 variants were investigated in normal colonic mucosa, the lymph nodes which was histopathologically free of cancer cell, and cancer tissues of 44 human colorectal cancer patients by RT-PCR method. The expression of CD44V was observed in 28 out of 39 (71.8%) tumors and 7 out of 11 (63.6%) N1 normal regional lymph nodes, and CD44V6/7 was observed in 28 out of 39 (71.8%) tumors and 9 out of 11 (81.8%) N1 normal regional lymph nodes. The expressions of CD44V and CD44V6/7 were most frequently observed compared with any other CD44 variants. In normal colonic mucosa, the expression of CD44 variants are low but in cancer tissue and its regional lymph node, the expression of CD44V and CD44V6/7 were significantly higher and more frequent than any other CD44 variants (p<0.05). These results suggest that CD44V and CD44V6/7 can be a molecular marker for colorectal cancer and its micrometastasis to the regional normal lymph node.

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Year:  2000        PMID： 11194197      PMCID： PMC3054696          DOI： 10.3346/jkms.2000.15.6.696

Source DB:  PubMed          Journal:  J Korean Med Sci        ISSN： 1011-8934            Impact factor:   2.153


  2 in total

1.  The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags.

Authors:  Helena Brentani; Otávia L Caballero; Anamaria A Camargo; Aline M da Silva; Wilson Araújo da Silva; Emmanuel Dias Neto; Marco Grivet; Arthur Gruber; Pedro Edson Moreira Guimaraes; Winston Hide; Christian Iseli; C Victor Jongeneel; Janet Kelso; Maria Aparecida Nagai; Elida Paula Benquique Ojopi; Elisson C Osorio; Eduardo M R Reis; Gregory J Riggins; Andrew John George Simpson; Sandro de Souza; Brian J Stevenson; Robert L Strausberg; Eloiza H Tajara; Sergio Verjovski-Almeida; Marcio Luis Acencio; Mário Henrique Bengtson; Fabiana Bettoni; Walter F Bodmer; Marcelo R S Briones; Luiz Paulo Camargo; Webster Cavenee; Janete M Cerutti; Luis Eduardo Coelho Andrade; Paulo César Costa dos Santos; Maria Cristina Ramos Costa; Israel Tojal da Silva; Marcos Roberto H Estécio; Karine Sa Ferreira; Frank B Furnari; Milton Faria; Pedro A F Galante; Gustavo S Guimaraes; Adriano Jesus Holanda; Edna Teruko Kimura; Maarten R Leerkes; Xin Lu; Rui M B Maciel; Elizabeth A L Martins; Katlin Brauer Massirer; Analy S A Melo; Carlos Alberto Mestriner; Elisabete Cristina Miracca; Leandro Lorenco Miranda; Francisco G Nobrega; Paulo S Oliveira; Apua C M Paquola; José Rodrigo C Pandolfi; Maria Ines de Moura Campos Pardini; Fabio Passetti; John Quackenbush; Beatriz Schnabel; Mari Cleide Sogayar; Jorge E Souza; Sandro R Valentini; Andre C Zaiats; Elisabete Jorge Amaral; Liliane A T Arnaldi; Amelia Goes de Araújo; Simone Aparecida de Bessa; David C Bicknell; Maria Eugenia Ribeiro de Camaro; Dirce Maria Carraro; Helaine Carrer; Alex F Carvalho; Christian Colin; Fernando Costa; Cyntia Curcio; Ismael Dale Cotrim Guerreiro da Silva; Neusa Pereira da Silva; Márcia Dellamano; Hamza El-Dorry; Enilza Maria Espreafico; Ari José Scattone Ferreira; Cristiane Ayres Ferreira; Maria Angela H Z Fortes; Angelita Habr Gama; Daniel Giannella-Neto; Maria Lúcia C C Giannella; Ricardo R Giorgi; Gustavo Henrique Goldman; Maria Helena S Goldman; Christine Hackel; Paulo Lee Ho; Elza Myiuki Kimura; Luiz Paulo Kowalski; Jose E Krieger; Luciana C C Leite; Ademar Lopes; Ana Mercedes S C Luna; Alan Mackay; Suely Kazue Nagahashi Mari; Adriana Aparecida Marques; Waleska K Martins; André Montagnini; Mario Mourão Neto; Ana Lucia T O Nascimento; A Munro Neville; Marina P Nobrega; Mike J O'Hare; Audrey Yumi Otsuka; Anna Izabel Ruas de Melo; Maria Luisa Paco-Larson; Gonçalo Guimarães Pereira; Neusa Pereira da Silva; Joao Bosco Pesquero; Juliana Gilbert Pessoa; Paula Rahal; Claudia Aparecida Rainho; Vanderlei Rodrigues; Silvia Regina Rogatto; Camila Malta Romano; Janaina Gusmao Romeiro; Benedito Mauro Rossi; Monica Rusticci; Renata Guerra de Sá; Simone Cristina Sant' Anna; Miriam L Sarmazo; Teresa Cristina de Lima E Silva; Fernando Augusto Soares; Maria de Fátima Sonati; Josane de Freitas Sousa; Diana Queiroz; Valéria Valente; André Luiz Vettore; Fabiola Elizabeth Villanova; Marco Antonio Zago; Heloisa Zalcberg
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-30       Impact factor: 11.205

2.  Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage, histopathological grade of malignancy and clinical features.

Authors:  Bogdan Zalewski
Journal:  World J Gastroenterol       Date:  2004-02-15       Impact factor: 5.742
  2 in total

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