Literature DB >> 11193797

The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?

B A Yankner1.   

Abstract

A central issue in Alzheimer's disease research is whether amyloid beta-protein (A beta) is a cause or effect of the pathogenic process. Several independent lines of evidence argue for causality, although human clinical trials may be required to finally settle the issue.

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Year:  2000        PMID： 11193797     DOI： 10.1111/j.1749-6632.2000.tb05555.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  11 in total

1.  3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit.

Authors:  Isabella Russo; Luca Caracciolo; David Tweedie; Sang-Ho Choi; Nigel H Greig; Sergio Barlati; Francesca Bosetti
Journal:  J Neurochem       Date:  2012-07-25       Impact factor: 5.372

Review 2.  Neuroprotective strategies in Alzheimer's disease.

Authors:  Frank M Longo; Stephen M Massa
Journal:  NeuroRx       Date:  2004-01

3.  Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.

Authors:  Shiyong Peng; Diego J Garzon; Monica Marchese; William Klein; Stephen D Ginsberg; Beverly M Francis; Howard T J Mount; Elliott J Mufson; Ahmad Salehi; Margaret Fahnestock
Journal:  J Neurosci       Date:  2009-07-22       Impact factor: 6.167

4.  Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity.

Authors:  R Varma; Y Chai; J Troncoso; J Gu; H Xing; S S Stojilkovic; M P Mattson; N J Haughey
Journal:  Neuromolecular Med       Date:  2009-06-27       Impact factor: 3.843

Review 5.  Cortical excitability and neurology: insights into the pathophysiology.

Authors:  Radwa A B Badawy; Tobias Loetscher; Richard A L Macdonell; Amy Brodtmann
Journal:  Funct Neurol       Date:  2012 Jul-Sep

6.  Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.

Authors:  E M Sigurdsson; H Scholtzova; P D Mehta; B Frangione; T Wisniewski
Journal:  Am J Pathol       Date:  2001-08       Impact factor: 4.307

7.  Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity.

Authors:  Nelson Arispe; Juan Carlos Diaz; Michael Flora
Journal:  Biophys J       Date:  2008-08-22       Impact factor: 4.033

8.  Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.

Authors:  David Tweedie; Ryan A Ferguson; Kelly Fishman; Kathryn A Frankola; Henriette Van Praag; Harold W Holloway; Weiming Luo; Yazhou Li; Luca Caracciolo; Isabella Russo; Sergio Barlati; Balmiki Ray; Debomoy K Lahiri; Francesca Bosetti; Nigel H Greig; Susanna Rosi
Journal:  J Neuroinflammation       Date:  2012-05-29       Impact factor: 8.322

9.  Genetic studies in Alzheimer's disease.

Authors:  Ya-Ping Tang; Elliot S Gershon
Journal:  Dialogues Clin Neurosci       Date:  2003-03       Impact factor: 5.986

10.  RIG-1 receptor expression in the pathology of Alzheimer's disease.

Authors:  Juan Pablo de Rivero Vaccari; Frank J Brand; Christina Sedaghat; Deborah C Mash; W Dalton Dietrich; Robert W Keane
Journal:  J Neuroinflammation       Date:  2014-04-02       Impact factor: 8.322
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