Literature DB >> 11193785

Genetic factors in the genesis of Alzheimer's disease.

P H St George-Hyslop1.   

Abstract

At least four different genes have been identified that are associated with inherited susceptibiltiy to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, beta APP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.

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Year:  2000        PMID： 11193785     DOI： 10.1111/j.1749-6632.2000.tb05552.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  20 in total

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3.  CYP46A1 and the APOEε4 Allele Polymorphisms Correlate with the Risk of Alzheimer's Disease.

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Review 5.  Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

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Review 6.  Transgenic models of Alzheimer's disease: learning from animals.

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Review 7.  The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease.

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8.  Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease.

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Journal:  Exp Neurol       Date:  2006-10-27       Impact factor: 5.330

Review 9.  CYP46A1 T/C polymorphism associated with the APOE ε4 allele increases the risk of Alzheimer's disease.

Authors:  Ling Li; Zegang Yin; Juan Liu; Gongbo Li; Yanjiang Wang; Jiachuan Yan; Huadong Zhou
Journal:  J Neurol       Date:  2012-10-16       Impact factor: 4.849

10.  Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

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Journal:  Am J Pathol       Date:  2004-04       Impact factor: 4.307
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