H H Lin1, J H Kao. 1. Department of Obstetrics and Gynaecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Republic of China.
Abstract
OBJECTIVE: To assess whether pregnancy and delivery influence serum levels of hepatitis C virus (HCV) in carrier mothers. DESIGN: A prospective study. SETTING: University department of obstetrics and gynaecology. PARTICIPANTS: Ten pregnant HCV carriers (group A) and 8 nonpregnant HCV carriers (group B). METHODS: Serum samples were collected for group A at first and third trimesters, delivery, postpartum 1, 3, 6, 9 and 12 months, and at every three months for 1 year for group B. MAIN OUTCOME MEASURES: Each serum sample was tested for serum alanine aminotransferase (ALT), anti-HCV titre and HCV-cDNA concentration by a competitive polymerase chain reaction (PCR) with a sensitivity of 250 copies/mL serum. RESULTS: In group A, the HCV levels remained unremarkably changed during pregnancy and delivery. However, all women had decreased HCV levels 1 and 3 months after delivery. Two women had undetectable serum HCV level postpartum and thereafter. Serum ALT values in 3 women were sporadically elevated, but did not correlate with decreased serum HCV levels. Anti-HCV titres remained unchanged during the study period. In two women from group B, the serum HCV levels were undetectable during follow up. Other 6 women showed fluctuations in the serum HCV levels but all were above 250 copies/mL. Serum ALT values were normal and anti-HCV titres remained stationary in all 8 nonpregnant carriers. CONCLUSION: Serum HCV levels are decreased 1 and 3 months after delivery. This fact might suggest that puerperium is an optimal time for antiviral therapy in HCV carrier mothers.
OBJECTIVE: To assess whether pregnancy and delivery influence serum levels of hepatitis C virus (HCV) in carrier mothers. DESIGN: A prospective study. SETTING: University department of obstetrics and gynaecology. PARTICIPANTS: Ten pregnant HCV carriers (group A) and 8 nonpregnant HCV carriers (group B). METHODS: Serum samples were collected for group A at first and third trimesters, delivery, postpartum 1, 3, 6, 9 and 12 months, and at every three months for 1 year for group B. MAIN OUTCOME MEASURES: Each serum sample was tested for serum alanine aminotransferase (ALT), anti-HCV titre and HCV-cDNA concentration by a competitive polymerase chain reaction (PCR) with a sensitivity of 250 copies/mL serum. RESULTS: In group A, the HCV levels remained unremarkably changed during pregnancy and delivery. However, all women had decreased HCV levels 1 and 3 months after delivery. Two women had undetectable serum HCV level postpartum and thereafter. Serum ALT values in 3 women were sporadically elevated, but did not correlate with decreased serum HCV levels. Anti-HCV titres remained unchanged during the study period. In two women from group B, the serum HCV levels were undetectable during follow up. Other 6 women showed fluctuations in the serum HCV levels but all were above 250 copies/mL. Serum ALT values were normal and anti-HCV titres remained stationary in all 8 nonpregnant carriers. CONCLUSION: Serum HCV levels are decreased 1 and 3 months after delivery. This fact might suggest that puerperium is an optimal time for antiviral therapy in HCV carrier mothers.
Authors: Jonathan R Honegger; Dana Tedesco; Jennifer A Kohout; Mona R Prasad; Aryn A Price; Tera Lindquist; Samantha Ohmer; Melissa Moore-Clingenpeel; Arash Grakoui; Christopher M Walker Journal: Proc Natl Acad Sci U S A Date: 2016-09-06 Impact factor: 11.205
Authors: Angeles Ruiz-Extremera; José Antonio Muñoz-Gámez; Ana Abril-Molina; María Angustias Salmerón-Ruiz; Paloma Muñoz-de-Rueda; Esther José Pavón-Castillero; Rosa Quiles-Pérez; Angel Carazo; Ana Gila; Sergio Manuel Jimenez-Ruiz; Jorge Casado; Ana Belén Martín; Laura Sanjuán-Núñez; Esther Ocete-Hita; Julián López Viota; Josefa León; Javier Salmerón Journal: PLoS One Date: 2013-10-10 Impact factor: 3.240
Authors: Jonathan R Honegger; Seungtaek Kim; Aryn A Price; Jennifer A Kohout; Kevin L McKnight; Mona R Prasad; Stanley M Lemon; Arash Grakoui; Christopher M Walker Journal: Nat Med Date: 2013-10-27 Impact factor: 53.440