AIM: To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. RESULTS: Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A. CONCLUSION: These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism.
AIM: To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. RESULTS: Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A. CONCLUSION: These results further support that cannabinoidCB1 receptor blockade may have a potential utility for the treatment of alcoholism.
Authors: Antonia Serrano; Patricia Rivera; Francisco J Pavon; Juan Decara; Juan Suárez; Fernando Rodriguez de Fonseca; Loren H Parsons Journal: Alcohol Clin Exp Res Date: 2011-12-05 Impact factor: 3.455
Authors: M Navarro; M R Carrera; W Fratta; O Valverde; G Cossu; L Fattore; J A Chowen; R Gomez; I del Arco; M A Villanua; R Maldonado; G F Koob; F Rodriguez de Fonseca Journal: J Neurosci Date: 2001-07-15 Impact factor: 6.167
Authors: J Hirvonen; P Zanotti-Fregonara; J C Umhau; D T George; D Rallis-Frutos; C H Lyoo; C-T Li; C S Hines; H Sun; G E Terry; C Morse; S S Zoghbi; V W Pike; R B Innis; M Heilig Journal: Mol Psychiatry Date: 2012-07-10 Impact factor: 15.992
Authors: K Yaragudri Vinod; Paola Maccioni; Maria Salud Garcia-Gutierrez; Teresa Femenia; Shan Xie; Mauro A M Carai; Jorge Manzanares; Thomas B Cooper; Basalingappa L Hungund; Giancarlo Colombo Journal: Addict Biol Date: 2011-02-11 Impact factor: 4.280
Authors: José Antonio López-Moreno; Gustavo González-Cuevas; Fernando Rodríguez de Fonseca; Miguel Navarro Journal: J Neurosci Date: 2004-09-22 Impact factor: 6.167