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Literature DB >> 11188699

DNA mismatch repair: the hands of a genome guardian.

Abstract

DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.

Entities: Chemical

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Year: 2000 PMID： 11188699 DOI： 10.1016/s0969-2126(00)00545-1

Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006

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Cited

8 in total

1. Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.

Authors: Edwin Antony; Manju M Hingorani
Journal: Biochemistry Date: 2003-07-01 Impact factor: 3.162

Review 2. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.

Authors: Gareth J Williams; Susan P Lees-Miller; John A Tainer
Journal: DNA Repair (Amst) Date: 2010-10-28

3. Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex.

Authors: Victoria V Hargreaves; Scarlet S Shell; Dan J Mazur; Martin T Hess; Richard D Kolodner
Journal: J Biol Chem Date: 2010-01-20 Impact factor: 5.157

4. Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair.

Authors: Victoria V Hargreaves; Christopher D Putnam; Richard D Kolodner
Journal: J Biol Chem Date: 2012-10-08 Impact factor: 5.157

DNA mismatch repair: the hands of a genome guardian.

1. Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.

Review 2. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.

3. Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex.

4. Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair.

5. DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.

Review 6. Exploiting DNA Endonucleases to Advance Mechanisms of DNA Repair.

7. Characterization of multi-functional properties and conformational analysis of MutS2 from Thermotoga maritima MSB8.

8. Conformational changes of a Swi2/Snf2 ATPase during its mechano-chemical cycle.