Literature DB >> 11186109

Brainstem function in rapid eye movement sleep behavior disorder: the evaluation of brainstem function by proton MR spectroscopy (1H-MRS).

M Miyamoto1, T Miyamoto, J Kubo, N Yokota, K Hirata, T Sato.   

Abstract

Brainstem function was evaluated by proton magnetic resonance (MR) spectroscopy (1H-MRS) in a 69-year-old man with idiopathic rapid eye movement (REM) sleep behavior disorder. An analysis of spectral peak area ratios revealed an increase in the choline/creatine ratio. This change suggests that brainstem neurons have functional impairment at the cell membrane level. Further, our results suggest that 1H-MRS may provide for non-invasive, metabolic evaluation of brainstem neuronal function in REM sleep behavior disorder and find application in the differentiation of secondary REM sleep behavior disorders with neurodegenerative disorders from idiopathic disorders.

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Year:  2000        PMID： 11186109     DOI： 10.1046/j.1440-1819.2000.00710.x

Source DB:  PubMed          Journal:  Psychiatry Clin Neurosci        ISSN： 1323-1316            Impact factor:   5.188


  6 in total

Review 1.  Pathophysiologic mechanisms in REM sleep behavior disorder.

Authors:  Mark W Mahowald; Carlos H Schenck; Michel A Cramer Bornemann
Journal:  Curr Neurol Neurosci Rep       Date:  2007-03       Impact factor: 5.081

2.  New pathways and data on rapid eye movement sleep behaviour disorder in a rat model.

Authors:  Kung-Chiao Hsieh; Darian Nguyen; Jerome M Siegel; Yuan-Yang Lai
Journal:  Sleep Med       Date:  2012-10-09       Impact factor: 3.492

Review 3.  REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions.

Authors:  Bradley F Boeve
Journal:  Ann N Y Acad Sci       Date:  2010-01       Impact factor: 5.691

4.  Diffusion tensor imaging in idiopathic REM sleep behavior disorder reveals microstructural changes in the brainstem, substantia nigra, olfactory region, and other brain regions.

Authors:  Marcus M Unger; Marcus Belke; Katja Menzler; Johannes T Heverhagen; Boris Keil; Karin Stiasny-Kolster; Felix Rosenow; Nico J Diederich; Geert Mayer; Jens C Möller; Wolfgang H Oertel; Susanne Knake
Journal:  Sleep       Date:  2010-06       Impact factor: 5.849

Review 5.  Neuroimaging insights into the pathophysiology of sleep disorders.

Authors:  Martin Desseilles; Thanh Dang-Vu; Manuel Schabus; Virginie Sterpenich; Pierre Maquet; Sophie Schwartz
Journal:  Sleep       Date:  2008-06       Impact factor: 5.849

Review 6.  Review of rapid eye movement behavior sleep disorders.

Authors:  Vivien C Abad; Christian Guilleminault
Journal:  Curr Neurol Neurosci Rep       Date:  2004-03       Impact factor: 5.081
  6 in total

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