Literature DB >> 11185394

Neuroscience. An antibiotic to treat Alzheimer's?

L Helmuth.   

Abstract

An antibiotic once used to treat traveler's diarrhea might battle Alzheimer's disease as well, researchers announced here last week at the Society for Neuroscience's annual meeting. The drug dissolves Alzheimer's-like plaques in mouse brains, apparently by trapping the copper and zinc that stud these deposits. A clinical trial to test whether the drug helps people with Alzheimer's is already under way.

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Year:  2000        PMID： 11185394     DOI： 10.1126/science.290.5495.1273a

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

Review 1.  Alzheimer's disease in man and transgenic mice: females at higher risk.

Authors:  R S Turner
Journal:  Am J Pathol       Date:  2001-03       Impact factor: 4.307

Review 2.  Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders.

Authors:  Silvio R Bareggi; Umberto Cornelli
Journal:  CNS Neurosci Ther       Date:  2010-12-27       Impact factor: 5.243

3.  Evaluation of anti-prionic activity of clioquinol in an in vivo model (Mesocricetus auratus).

Authors:  C Pollera; B Lucchini; E Formentin; S Bareggi; G Poli; W Ponti
Journal:  Vet Res Commun       Date:  2005-08       Impact factor: 2.459

Review 4.  Clioquinol: To harm or heal.

Authors:  Dominique R Perez; Larry A Sklar; Alexandre Chigaev
Journal:  Pharmacol Ther       Date:  2019-03-18       Impact factor: 12.310

5.  Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A.

Authors:  Virginia Roxas-Duncan; Istvan Enyedy; Vicki A Montgomery; Vanessa S Eccard; Marco A Carrington; Huiguo Lai; Nizamettin Gul; David C H Yang; Leonard A Smith
Journal:  Antimicrob Agents Chemother       Date:  2009-06-15       Impact factor: 5.191

6.  Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia.

Authors:  Yunwon Moon; Sehyun Chae; Sujin Yim; Eun Gyeong Yang; Jungwoo Choe; Jiyeon Hyun; Rakwoo Chang; Daehee Hwang; Hyunsung Park
Journal:  iScience       Date:  2022-06-03

7.  Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.

Authors:  Padma Singh; Manglesh Kumar Singh; Dilip Chaudhary; Vinita Chauhan; Pranay Bharadwaj; Apurva Pandey; Nisha Upadhyay; Ram Kumar Dhaked
Journal:  PLoS One       Date:  2012-10-11       Impact factor: 3.240
  7 in total

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