Literature DB >> 11182314

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

D A Braasch1, D R Corey.   

Abstract

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.

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Year:  2001        PMID： 11182314     DOI： 10.1016/s1074-5521(00)00058-2

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  163 in total

1.  Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design.

Authors:  Dwaine A Braasch; Yinghui Liu; David R Corey
Journal:  Nucleic Acids Res       Date:  2002-12-01       Impact factor: 16.971

2.  Use of locked nucleic acid oligonucleotides to add functionality to plasmid DNA.

Authors:  Kirsten M L Hertoghs; Jonathan H Ellis; Ian R Catchpole
Journal:  Nucleic Acids Res       Date:  2003-10-15       Impact factor: 16.971

3.  NMR solution structure of a parallel LNA quadruplex.

Authors:  Antonio Randazzo; Veronica Esposito; Oliver Ohlenschläger; Ramadurai Ramachandran; Luciano Mayola
Journal:  Nucleic Acids Res       Date:  2004-06-04       Impact factor: 16.971

4.  DNA mapping using microfluidic stretching and single-molecule detection of fluorescent site-specific tags.

Authors:  Eugene Y Chan; Nuno M Goncalves; Rebecca A Haeusler; Amie J Hatch; Jonathan W Larson; Anthony M Maletta; Gregory R Yantz; Eugene D Carstea; Martin Fuchs; Gordon G Wong; Steven R Gullans; Rudolf Gilmanshin
Journal:  Genome Res       Date:  2004-06       Impact factor: 9.043

5.  Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR.

Authors:  Matthew P Johnson; Larisa M Haupt; Lyn R Griffiths
Journal:  Nucleic Acids Res       Date:  2004-03-26       Impact factor: 16.971

Review 6.  Beyond DNA origami: the unfolding prospects of nucleic acid nanotechnology.

Authors:  Nicole Michelotti; Alexander Johnson-Buck; Anthony J Manzo; Nils G Walter
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2011-11-30

7.  Locked nucleic acid and flow cytometry-fluorescence in situ hybridization for the detection of bacterial small noncoding RNAs.

Authors:  Kelly L Robertson; Gary J Vora
Journal:  Appl Environ Microbiol       Date:  2011-11-04       Impact factor: 4.792

8.  Monitoring viral RNA in infected cells with LNA flow-FISH.

Authors:  Kelly L Robertson; Anne Brooks Verhoeven; Dzung C Thach; Eddie L Chang
Journal:  RNA       Date:  2010-06-28       Impact factor: 4.942

Review 9.  Allele-selective inhibition of trinucleotide repeat genes.

Authors:  Masayuki Matsui; David R Corey
Journal:  Drug Discov Today       Date:  2012-01-18       Impact factor: 7.851

Review 10.  Modulation of immune responses following solid organ transplantation by microRNA.

Authors:  Nayan J Sarma; Venkataswarup Tiriveedhi; Sabarinathan Ramachandran; Jeffrey Crippin; William Chapman; T Mohanakumar
Journal:  Exp Mol Pathol       Date:  2012-10-01       Impact factor: 3.362
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