Literature DB >> 11182275

Profenofos metabolites in human poisoning.

M Gotoh1, M Sakata, T Endo, H Hayashi, H Seno, O Suzuki.   

Abstract

Profenofos and its metabolites were determined in a case of fatal poisoning. Little profenofos and large amounts of metabolites were detected by gas chromatography/flame photometric detection in the acid extracts of blood and urine after methylation with diazomethane. Four major metabolites containing phosphorus were identified with the synthesized metabolites, namely, despropylated profenofos, desethylated profenofos and des-S-propylated profenofos, respectively. 4-Bromo-2-chlorophenol (BCP), an aryl moiety of profenofos, was also determined in blood and urine with high performance liquid chromatograph (HPLC) as free or conjugated metabolites.

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Year:  2001        PMID： 11182275     DOI： 10.1016/s0379-0738(00)00377-7

Source DB:  PubMed          Journal:  Forensic Sci Int        ISSN： 0379-0738            Impact factor:   2.395


  5 in total

1.  Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker.

Authors:  Oswald A Dadson; Corie A Ellison; Steven T Singleton; Lai-Har Chi; Barbara P McGarrigle; Pamela J Lein; Fayssal M Farahat; Taghreed Farahat; James R Olson
Journal:  Toxicology       Date:  2013-02-08       Impact factor: 4.221

2.  Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers.

Authors:  Steven T Singleton; Pamela J Lein; Oswald A Dadson; Barbara P McGarrigle; Fayssal M Farahat; Taghreed Farahat; Matthew R Bonner; Richard A Fenske; Kit Galvin; Michael R Lasarev; W Kent Anger; Diane S Rohlman; James R Olson
Journal:  Int J Hyg Environ Health       Date:  2014-11-07       Impact factor: 5.840

3.  Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry.

Authors:  Isaac Omwenga; Shensheng Zhao; Laetitia Kanja; Hans Mol; Ivonne M C M Rietjens; Jochem Louisse
Journal:  Arch Toxicol       Date:  2021-03-02       Impact factor: 5.153

4.  Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos.

Authors:  M Eddleston; F Worek; P Eyer; H Thiermann; L Von Meyer; K Jeganathan; M H R Sheriff; A H Dawson; N A Buckley
Journal:  QJM       Date:  2009-09-08

5.  Photoresponsive Surface Molecularly Imprinted Polymers for the Detection of Profenofos in Tomato and Mangosteen.

Authors:  Mei-Jun Chen; Hai-Lin Yang; Ya-Min Si; Qian Tang; Cheuk-Fai Chow; Cheng-Bin Gong
Journal:  Front Chem       Date:  2020-10-09       Impact factor: 5.221
  5 in total

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