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Literature DB >> 11181485

Regulation of cytochrome p450 by inflammatory mediators: why and how?

Abstract

Expression and activities of cytochrome P450 enzymes are down-regulated in the liver during the host response to inflammation or infection, leading to alterations in drug clearance and toxin activation. This review focuses on recent studies on the mechanisms of this down-regulation, as well as the cytokines and cell types involved. Possible reasons for cytochrome P450 down-regulation are discussed.

Entities: Disease Gene

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Year: 2001 PMID： 11181485

Source DB: PubMed Journal: Drug Metab Dispos ISSN： 0090-9556 Impact factor: 3.922

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Cited

104 in total

1. Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.

Authors: Jian Yang; Chunshu Hao; Dongfang Yang; Deshi Shi; Xiulong Song; Xiaofei Luan; Gang Hu; Bingfang Yan
Journal: Toxicol Lett Date: 2010-06-09 Impact factor: 4.372

2. Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology.

Authors: Paula M Ferreira; Raquel Catarino; Deolinda Pereira; Ana Matos; Daniela Pinto; Ana Coelho; Carlos Lopes; Rui Medeiros
Journal: Eur J Clin Pharmacol Date: 2005-12-22 Impact factor: 2.953

3. Transcriptional suppression of CYP2A13 expression by lipopolysaccharide in cultured human lung cells and the lungs of a CYP2A13-humanized mouse model.

Authors: Hong Wu; Zhihua Liu; Guoyu Ling; David Lawrence; Xinxin Ding
Journal: Toxicol Sci Date: 2013-07-24 Impact factor: 4.849

4. Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications.

Authors: Wanji Seo; Alexandr A Kapralov; Galina V Shurin; Michael R Shurin; Valerian E Kagan; Alexander Star
Journal: Nanoscale Date: 2015-05-21 Impact factor: 7.790

Regulation of cytochrome p450 by inflammatory mediators: why and how?

1. Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.

2. Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology.

3. Transcriptional suppression of CYP2A13 expression by lipopolysaccharide in cultured human lung cells and the lungs of a CYP2A13-humanized mouse model.

4. Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications.

Review 5. Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes.

6. Regulation of cytochrome P450 4F11 by nuclear transcription factor-κB.

7. The effects of intestinal LPS exposure on inflammatory responses in a porcine enterohepatic co-culture system.

8. Therapeutic benefits of budesonide in gastroenterology.

9. Variability in drug metabolizing enzyme activity in HIV-infected patients.

10. Roles of nitric oxide in inflammatory downregulation of human cytochromes P450.